摘要
家族性胃癌（FGC）成因包括E-钙黏蛋白（CDH1）基因突变、幽门螺杆菌感染等因素。FGC患者中位年龄50～65岁，男女性别比约2：1，肿瘤多位于远端胃，组织学类型以弥漫型多见.有胃癌家族史，特别是父母为胃癌者患胃癌风险增加。当前的技术手段较难早期发现FGC，预防FGC的方法包括根治幽门螺杆菌、预防性全胃切除术等。
The etiology of familial gastric cancer （FGC） are E-cadherin （ CDH 1 ） mutations, helico- bacter pylori infection, etc. The median age of patients with FGC is 50-65 years old. The male-female sex ratio is 2 ： 1. The most of tumors of FGC locate in distal stomach and present diffuse type in histological classifica- tion. It is reported that the people who has a family history of gastric cancer especially for those parents has an increased risk of gastric cancer. It is difficult to find FGC in early stage by current technology. The preventive methods include eradication of helicobacter pylori and prophylactic total gastreetomy, etc.
出处
《国际肿瘤学杂志》
CAS
2013年第1期65-68,共4页
Journal of International Oncology
关键词
胃肿瘤
家庭
遗传
Stomach neoplasms
Family
Heredity
