摘要
目的通过分析先天性甲状腺功能减退症（CH）患儿甲状腺高锝酸盐显像结果，推断CH的病因，分析显像结果对预后及治疗的意义。方法经厦门新生儿疾病筛查分中心筛查并确诊为CH的患儿221例，口服高锝酸盐显像剂18．5～37．0MBq，服药后1h行甲状腺SPECT显像。结果221例CH患儿中，显像正常58例；甲状腺发育不良或异位37例；甲状腺术见显影52例；甲状腺体积增大，核素摄取增强74例。结论甲状腺核素显像有助于判断新生儿CH的病因，初步协助鉴别永久性甲减和暂时性甲减，从而帮助重新评估怀疑为暂时性甲减的患儿任替代治疗后的甲状腺功能，同时避免了永久性甲减患儿不必要的停药复查风险。
Objective To explore the value of 99^Fc^m-pertechnetate seintigraphy in determining the etiology of primary congenital hypothyroidism （CH）. Methods Two hundred and twenty one neonates with CH diagnosed by Xiamen newborn disease screening center received thyroid 99^Fc^m-perteehnetate scintigra- phy. Every case took 18.5-37.0 MBq 99^Fc^m-perteehnetate orally and thyroid SPECT was performed 1 h later. Results Four patterns of thyroid scintigrams were observed among the 221 cases of neonates with CH. Normal thyroid images were found in 58 cases. Thyroid hypopiasia or ectopie thyroid images were found in 37 cases. Nonvisualization of the thyroid glands were found in 52 cases. Goiter and radionuclide uptake enhancement were found in 74 cases. Conclusions Thyroid 99^Fc^m-pertechnetate seintigraphy can help to determine the underlying etiology of CH. This is useful in determining whether some cases are likely to be transient or permanent. It identifies those patients who do not need to be evaluated for transient hypothy- roidism and who should be given lifelong replacement therapy and indicates those patients who need re-evaluation.
出处
《国际放射医学核医学杂志》
2013年第1期24-26,共3页
International Journal of Radiation Medicine and Nuclear Medicine
