摘要
目的:观察联合检测血清SCCA、CA19-9和CA125水平在宫颈癌诊断及预后判断中的临床意义。方法:收集2007年1月~2011年12月收治的105例宫颈癌患者(宫颈癌组)及同期健康体检的40例妇女(对照组),分别检测血清肿瘤标志物SCCA、CA19-9和CA125水平,分析其与宫颈癌及临床分期、病理类型的关系,并观察其在初诊和复发病例中的含量差异。结果:与对照组比较,宫颈癌组血清SCCA、CA19-9和CA125含量和阳性率均显著增高,且其含量的高低与宫颈癌的临床分期密切相关;同时复发病例上述指标水平均显著高于初诊病例;SCCA在宫颈鳞癌中的水平和阳性率均显著高于宫颈腺癌,而CA19-9和CA125在宫颈鳞癌中的水平和阳性率均显著低于宫颈腺癌。结论:联合检测血清肿瘤标志物SCCA、CA19-9和CA125水平有助于宫颈癌的诊断和对其预后与病理类型的判断。
Objective: To observe the clinical significance of joint detection of serum squamous cell carcinoma antigen (SCCA) , CAI99, and CA125 for diagnosis and prognostie evaluation of cervical cancer. Methods: One hundred and five patients with cervical cancer (cervical cancer group) who were treated in the hospital from January, 2007 to December 2011 and forty women who received physical exami- nation during the same period (control group) were collected, the serum levels of SCCA, CA199 , and CA125 in the two groups were detected respectively; their relationships with cervical eancer, clinical stages, and pathological types were analyzed; the differences of the levels between patients of preliminary diagnosis and recurrent patients were observed. Results: Compared with control group, the serum contents and positive rates of SCCA, CA199, and CA12s in cervical cancer group increased significantly, and the contents were correlated with clinical sta- ges of cervical cancer; the serum contents and positive rates of SCCA, CA199, and CA125 in recurrent patients were significantly higher than those in patients of preliminary diagnosis; the serum level and positive rate of SCCA in cervical squamous cell careinoma were significantly higher than those in cervical adenocarcinoma; but tile serum levels of CA199 and CA125 in cervical squamous cell carcinoma were significantly lower than those in cervical adenocareinoma. Conclusion: Joint detection of serum SCCA, CA199 , and CA125 is conducive to diagnosis of cervical cancer and prediction of prognosis and pathological types.
出处
《中国妇幼保健》
CAS
北大核心
2013年第5期772-774,共3页
Maternal and Child Health Care of China
关键词
宫颈癌
诊断
预后
Cervical cancer
Diagnosis
Prognosis