摘要
目的:探讨血清抑制素B(INHB)早期预测卵巢储备功能的临床价值及干预治疗后对其妊娠率的影响。方法:通过检测血清抑制素B水平筛查出202例卵巢储备功能下降导致不孕的患者,随机分为A、B两组各101例。A组未经治疗直接促排卵,B组经人工周期治疗后促排卵,观察两组的周期妊娠率、临床妊娠率及B组治疗前后激素水平的变化。结果:A组周期妊娠率、临床妊娠率均低于B组,差异均有统计学意义(P<0.05);B组INHB水平治疗后较治疗前升高,差异有统计学意义(P<0.05)。结论:血清INHB水平可作为临床早期预测卵巢储备功能下降的指标之一。尽早给予合理的性激素治疗可使卵巢功能得到改善,提高妊娠率。
Objective： To explore the clinical value of serum inhibin B for early predicting decline of ovarian reserve function and the effect of interventional therapy on pregnancy rate. Methods： Two hundred and two patients with decline of ovarian reserve function - in- duced infertility who were screened out by detecting inhibin B level were randomly divided into group A and group B, 101 patients in each group. The patients in group A received direct ovulation induction without treatment, while the patients in group B received ovulation induc- tion after artificial menstrual cycle. The cycle pregnancy rates and clinical pregnancy rates in the two groups and changes of hormones levels before and after treatment in group B were observed. Results： The cycle pregnancy rate and clinical pregnancy rate in group A were statisti- cally significantly lower than those in group B （ P 〈 0. 05 ） ; inbibin level after treatment was statistically significantly higher than that before treatment in group B （P 〈 0. 05 ） . Conclusion ： Serum inhibin B level can be used as one index to early predict decline of ovarian reserve function, early and reasonable sex hormone therapy can improve ovarian function and raise pregnancy rate.
出处
《中国妇幼保健》
CAS
北大核心
2013年第5期807-809,共3页
Maternal and Child Health Care of China
关键词
抑制素
卵巢储备功能
促排卵
Inhibin
Ovarian reserve function
Ovulation induction
