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γ干扰素释放试验在肺结核早期诊断中的应用 被引量:22

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摘要 目的探讨γ干扰素释放试验(IGRAs)在肺结核早期诊断中的应用价值。方法选择初次确诊的肺结核患者152例(观察组),健康体检者43例(对照组),行IGRAs及结核菌素皮试(TST)。结果观察组治疗前IGRAs阳性率为90.79%、TST阳性率为45.39%,两者比较P<0.05;对照组治疗前IGRAs阳性率为6.98%、TST阳性率为16.28%,两者比较P<0.05;观察组与对照组比较,P均<0.05。IGRAs诊断肺结核敏感性90.79%、特异性93.02%、阳性预测值97.87%、阴性预测值74.07%、Yuden指数0.838,TST分别为45.39%、73.72%、90.79%、30.25%、0.191。观察组治疗前后IGRAs阳性率分别为90.79%、26.31%,两者比较,P<0.05。结论 IGRAs用于肺结核诊断敏感性、特异性较高。
出处 《山东医药》 CAS 2013年第3期82-84,共3页 Shandong Medical Journal
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  • 1Ramos JM,Robledano C,Masiá M. Contribution of Interferon gamma release assays testing to the diagnosis of latent tuberculosis infection in HIV-infected patients:A comparison of QuantiFERON-TB gold in tube,T-SPOT.TB and tuberculin skin test[J].BMC Infectious Diseases,2012,(01):169.
  • 2Taki-Eddin L,Monem F. Utility of an interferon-gamma release assay as a potential diagnostic aid for active pulmonary tuberculosis[J].J Infect Dev Ctries,2012,(01):67-72.
  • 3Al-Attiyah R,Mustafa AS,Abal AT. Restoration of mycobacterial antigen-induced proliferation and interferon-gamma responses in peripheral blood mononuclear cells of tuberculosis patients upon effective chemotherapy[J].FEMS Immunology and Medical Microbiology,2003,(03):249-256.
  • 4Takayanagi K,Aoki M,Aman K. Analysis of an interferongamma release assay for monitoring the efficacy of anti-tuberculosis chemotherapyl[J].Japanese Journal of Infectious Diseases,2011,(02):133-138.
  • 5LoBue PA,Castro KG. Is it time to replace the tuberculin skin test with a blood test[J].Journal of the American Medical Association,2012,(03):241-242.
  • 6Kleinert S,Tony HP,Krueger K. Screening for latent tuberculosis infection:performance of tuberculin skin test and interferonγ release assays under real-life conditions[J].Annals of the Rheumatic Diseases,2012,(11):1791-1795.
  • 7Kobashi Y,Abe M,Mouri K. Usefulness of tuberculin skin test and three interferon-gamma release assays for the differential diagnosis of pulmonary tuberculosis[J].Internal Medicine,2012,(10):1199-1205.

同被引文献234

  • 1李红,唐神结,史祥,崔海燕,顾瑾,杨妍,何娅,桂徐蔚,方勇,郝晓辉,蒋瑞华.全血γ-干扰素释放试验对涂阴肺结核诊断价值的研究[J].中华临床医师杂志(电子版),2012,6(16):4894-4897. 被引量:52
  • 2郭华,王莹.结核分枝杆菌特异性抗原γ-干扰素释放试验临床应用评价[J].现代预防医学,2012,39(22):5915-5917. 被引量:5
  • 3张宜文,王庆,史清明,王东萍,陈艳.结核分枝杆菌感染T细胞斑点试验的临床应用价值[J].结核病与肺部健康杂志,2013,2(1). 被引量:4
  • 4Papay P, Eser A, Winkler S, Frantal S. et al. Factors impacting the results of interferon - γ release assay and tuberculin skin test in routine screening for latent tuberculosis in patients with inflammatory bowel diseases[ J]. Inflamm Bowel Dis, 2011,17 ( 1 ) :84 - 90.
  • 5Sayyahfar S, Karimi A, Fahimzad A, et al. Comparison of Tuberculin Skin Test result and interferon gamma response tohuman PPD in BCG scar positive and negative children [J]. J Epidemiol Glob Health, 2014,4 ( 1 ) :45 - 50.
  • 6Keng LT, Shu CC, Chen JY, et al. Evaluating pleural ADA, ADA2, IFN - γ and IGRA for diagnosing tuberculouspleurisy [ J ]. J Infect, 2013,67 (4) :294 - 302.
  • 7Cotter J, Rosa B. The importance of IGRA in patients candidates for biological therapy[J].J Crohns Colitis, 2013,7 ( 11 ) :928 - 929.
  • 8Al Jahdali H, Ahmed AE, Balkhy HH, et al. Comparison of the tuber- culin skin test and Quanti - FEIRON - TB Gold In - Tube ( QFT - G) test for the diagnosis of latent tuberculosis infection in dialysispatients [J]. J Infect Public Health, 2013,6(3) :166 -172.
  • 9KimSY, JungGS, KimSK, et al. Comparison of the tuberculin skin test and interferon-: release assay for the diagnosis of latent tuberculosis infection before kidney transplantation[ J]. Infection, 2013,41 ( 1 ) : 103-110.
  • 10Diel R, Loddenkemper R, Nienhaus A. Evidence-based comparison of commercial interferon-gamma release assays for detecting active TB: a meta analysis [ J ]. Chest, 2010,137 (4) :952-968.

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