摘要
猪肺炎支原体(Mycoplasma hyopneumoniae,Mhp)是引起猪支原体肺炎(Mycoplasma pneumoniae of Swine,MPS)的病原,给养猪业造成巨大的经济损失。由于对具有良好免疫原性的Mhp特异性蛋白缺少深入研究,使得Mhp在致病机制、血清学检测方法和新型疫苗的研究发展上受到一定限制,从而影响了对MPS的控制。本研究综合Mhp主要粘附因子、膜蛋白及细胞质蛋白等主要抗原蛋白的研究进展,为该病原致病机理研究、建立特异性诊断方法和推动基因工程疫苗发展提供一定的理论基础,对MPS的正确诊断、检测、免疫预防和控制也有重要意义。
Mycoplasma hyopneumoniae （Mhp） was the causative agent of Mycoplasma pneumoniae of Swine （MPS）,and causes huge economic losses to the pig industry.Due to the lack of depth study for immunogenic and specific proteins of Mhp,the development of the pathogenic mechanism,serological detection methods and new recombinant subunit vaccine research about Mhp were restricted to some extent,so it affected the control of MPS.In this article,the development of some major specific immunogenicity proteins （including adhesion,membrane proteins and cytoplasmic protein） research of Mhp were discussed,so as to provide theoretical basis and new ideas for the further research on the pathogenesis of Mycoplasma hyopneumoniae,the establishment of specific diagnostic methods and promoting the development of Mhp genetic engineering vaccine,it would play an important part in correctly diagnosis,detecting,the immunization and prevention of MPS.
出处
《中国农学通报》
CSCD
2013年第2期16-22,共7页
Chinese Agricultural Science Bulletin
基金
国家自然科学基金"猪呼吸道纤毛细胞对猪肺炎支原体强弱毒株感染应答的差异蛋白质组学研究"(31100136)
关键词
猪肺炎支原体
特异性抗原蛋白
特异性诊断方法
疫苗
Mycoplasma hyopneumoniae
specific immunogenicity proteins
specific diagnostic methods
vaccines
