摘要
目的探讨糖尿病与食管癌的关系。方法以"食管癌、食管肿瘤、糖尿病、esophageal cancer、esophageal neoplasms、diabetes mellitus"为关键词,计算机检索中国期刊全文数据库(CNKI)、中国生物医学文献数据库(CBM)、维普中文科技期刊数据库(VIP)、Cochrane Library、PubMed、EMbase和Ovid,检索时间均从建库至2012年4月。纳入所有研究糖尿病与食管癌病因相关性的病例-对照研究。采用RevMan 5.0软件进行Meta分析。结果最终纳入6篇病例对照研究,其中病例组(食管癌患者)1 553例,对照组(非肿瘤患者)57 767例;两组暴露糖尿病患者分别为139例和2 294例。Meta分析结果显示,各研究间存在统计学异质性〔合并效应量OR=1.60,95%CI(1.13,2.26)〕。亚组分析显示,无论男性还是女性,病例组的糖尿病患病率均较对照组增高,且女性较男性糖尿病人群的OR值更高〔女性:OR=1.58,95%CI(1.14,2.18);男性:OR=1.41,95%CI(1.07,1.86)〕。结论糖尿病与食管癌存在关联,提示糖尿病可能是食管癌的一个独立致病危险因素。
Objective To evaluate the association between diabetes mellitus（DM） and esophageal cancer（EC）. Methods We searched in CNKI,CBM,VIP,Cochrane Library,PubMed,EMbase and Ovid,etc.from databases establishment to April 2012 with the following Key words esophageal cancer,esophageal neoplasms,and diabetes mellitus.All the case-control studies on the association between DM and EC were included and the quality of them was assessed.Meta-analysis was conducted using the Cochrane Collaboration′s RevMan 5.0 software. Results A total of 6 case-control studies were included,with 1 553 cases in case group and 57 767 cases in control group.The DM patients in the two groups were 139 cases and 2 294 cases respectively.Meta analysis showed that there was statistical heterogeneity among studies（OR=1.60,95%CI（1.13,2.26））.Sub-group analysis showed that regardless of sex,the incidence of DM in case group was higher than in control group,and the OR in females was higher than in males（females：OR=1.58,95%CI（1.14,2.18）,males：OR=1.41,95%CI（1.07,1.86））. Conclusion DM is related to EC,indicating that DM may be an independent risk factor for EC.
出处
《中国全科医学》
CAS
CSCD
北大核心
2013年第3期289-291,297,共4页
Chinese General Practice
基金
上海市中等职业教育课程教学改革研究课题(24)
关键词
食管肿瘤
糖尿病
病例对照研究
危险因素
META分析
Esophageal neoplasms
Diabetes mellitus
Case-control studies
Risk factors
Meta-analysis
