摘要
目的探讨质子泵抑制剂（PPI）不良反应（ADR）的特点及相关因素，为临床合理用药提供参考。方法利用“维普医药信息镜像系统”、“万方数据医药信息镜像系统”、“中国医院数字图书馆”，对2001年1月～2011年12月国内公开报道的PPI所致的114ADR例进行统计分析。结果114例ADR患者中男性72例（63．16％），女性42例（36．84％），奥美拉唑最高79例（69．30％），临床主要表现为精神神经系统、消化系统、心血管系统等。结论临床应高度重视PH的ADR，以确保安全用药。
Objective To explore the features and contributing factors of adverse drug reaction（ADR） induced by proton pump inhibitors （PPIs） and provide rational use of drugs in clinic. Methods A statistical analysis was conducted on 114 cases of ADR publicly reported during the year from January 2001 to December 2011 via the use of VIP Medical Information System（VMIS）, Wanfang Medical Information System, and Chinese Hospital Digital Database. Results Of all the 114 cases, male patients amount to 72, accounting for 63.16%; Female 42 cases, comprising 36.84%. The ADR induced by Omeprazole reach up to 79 cases, making up 69.30%, and clinic ADR is mainly observed on the nervous system, the digestive system and the cardiovascular system. Conclusion High importance should be attached to the ADR induced by PPIs in clinic to ensure the safe use of drugs.
出处
《中国药物警戒》
2013年第1期39-41,共3页
Chinese Journal of Pharmacovigilance
