摘要
目的探讨磷酸酶基因(PTEN)与非小细胞肺癌(NSCLC)临床病理特征及预后的相关性。方法选择2007年3月～2008年6月65例NSCLC患者及23例正常肺组织石蜡标本,采用免疫组化检测各标本中PTEN蛋白表达,比较NSCLC组及正常肺组织组PTEN蛋白表达水平,分析PTEN蛋白表达与NSCLC患者性别、年龄、肿瘤大小、病理类型、淋巴结转移,病理分期及分化程度等临床病理特征的关系,并比较PTEN蛋白表达阳性及PTEN蛋白表达阴性NSCLC患者的平均生存时间和5年生存率。结果 NSCLC组PTEN蛋白阳性表达率(53.85%)显著低于正常肺组织组(91.30%),差异有高度统计学意义(P<0.01);NSCLC组织中PTEN蛋白阳性表达与肿瘤分化程度、病理分期及有无淋巴结转移有关,差异有统计学意义(P<0.05),而与患者性别、年龄、肿瘤大小及病理类型无关,差异无统计学意义(P>0.05);PTEN蛋白表达阳性的NSCLC患者平均生存时间[(54.80±10.07)个月]较PTEN蛋白表达阴性患者[(27.56±7.33)个月]显著延长,差异有高度统计学意义(P<0.01),其5年生存率(49.32%)亦显著高于PTEN蛋白表达阴性患者(17.40%),差异有高度统计学意义(P<0.01)。结论 PTEN蛋白在NSCLC组织中出现表达缺失,恶性程度越高、病理晚期(Ⅲ+Ⅳ期)及发生淋巴结转移的NSCLC组织PTEN蛋白表达越少,其预后越差。
Objective To explore the correlation between PTEN and clinicopathologic features as well as prognosis in non-small cell lung cancer（NSCLC）.Methods A total of 65 patients with NSCLC and 23 normal lung tissues from March 2007 to June 2008 were enrolled in this study,the expression of PTEN protein was detected by using immunohistochemistry assay and compared between NSCLC tissues and normal lung tissues,the correlations of expression of PTEN protein with gender,age,tumor in size,pathological types,lymph node metastasis,pathological stage and differentiation grade were analyzed,the mean survival and 5-year survival rate of PTEN positive and negative patients were also compared.Results The PTEN protein positive rate of NSCLC group（53.85%） was significantly lower than that of normal lung tissue group（91.30%）,the difference was statistically significant（P 0.01）.In NSCLC group,the expression of PTEN protein was related to differentiation grade,pathological stage and lymph node metastasis,the differences were statistically significant（P 0.05）,and were found no obvious relationship with gender,age,tumor in size and pathological types,the differences were not statistically significant（P 0.05）.The mean survival of PTEN protein positive NSCLC patients [（54.80±10.07） months] was longer than that of PTEN protein negative patients [（27.56±7.33） months],the difference was statistically significant（P 0.01）,the 5-year survival rate（49.32%） was also higher than that of protein negative patients（17.40%）,the difference was statistically significant（P 0.01）.Conclusion PTEN protein appears deletion in NSCLC tissues,its low expression has correlation with high degree of malignancy,late pathological stage（stage Ⅲ＋Ⅳ）,lymph node metastasis and accompanies poor prognosis.
出处
《中国医药导报》
CAS
2013年第1期98-100,共3页
China Medical Herald
关键词
非小细胞肺癌
磷酸酶基因
病理特征
预后
Non-small cell lung cancer
PTEN
Pathologic features
Prognosis
