期刊文献+

鼻咽癌患者放射治疗前后龋活性及唾液中钙、磷质量浓度的变化 被引量:5

Changes of caries activity and calcium,phosphorus concentrations in saliva of patients with nasopharyngeal carcinoma before and after radiotherapy
下载PDF
导出
摘要 目的探讨鼻咽癌患者放射治疗前后龋活性的变化,定量分析鼻咽癌患者放射治疗前后唾液中的钙、磷质量浓度的变化。方法选择鼻咽癌患者28例为试验组,健康志愿者20例为对照组。采用刃天青纸片法检测试验组放射治疗前、放射治疗(放射剂量为70 Gy)后龋活性的变化;采用火焰原子吸收光谱法和钼锑抗分光光度法测定试验组放射治疗前、放射治疗(放射剂量为70 Gy)后及对照组非刺激性唾液中钙、磷的质量浓度。结果试验组放射治疗后龋活性增加,与治疗前的差异有统计学意义(P<0.01)。试验组放射治疗前唾液中钙质量浓度为(63.19±3.27)mg.L-1,治疗后为(33.38±0.32)mg.L-1;放射治疗前磷质量浓度为(132.96±5.13)mg.L-1,治疗后为(49.18±2.66)mg.L-1。放射治疗前后唾液中钙、磷质量浓度的差异均有统计学意义(P<0.01),放射治疗后低于治疗前。结论鼻咽癌患者放射治疗后的龋活性增加,唾液中钙、磷质量浓度降低。 Objective To analyze caries activity of nasopharyngeal carcinoma (NPC) patients before and after radiation therapy. The study was also designed to analyze calcium and phosphorus concentrations in saliva of NPC patients before and after radiotherapy. Methods Twenty-eight NPC patients and 20 healthy controls were included in this study. Resazurin disc method was used to detect caries activity of NPC patients before and after 70 Gy radiothe- rapy. The atomic absorption spectrometry and molybdenum-stibium antispetrophotography method were used to analyze calcium and phosphorus concentrations in saliva of NPC patients before and after 70 Gy radiotherapy and the healthy controls. Results The results of resazurin disc method showed caries activity of NPC patients was increased after radiotherapy(P〈0.01). Calcium concentration in saliva of NPC patients before radiotherapy was (63.19±3.27) mg·L-1, phosphorus concentration was (132.96±5.13) mg·L-1. After 70 Gy radiotherapy, calcium concentration was (33.38± 0.32) mg·L-1, phosphorus concentration was (49.18±2.66) mg·L-~. The difference of calcium and phosphorus concen- trations in saliva before and after radiotherapy was significant (P〈0.01). Conclusion Caries activities of NPC patients increase after radiotherapy. Calcium and phosphorus concentrations in saliva decrease after radiation therapy.
出处 《华西口腔医学杂志》 CAS CSCD 北大核心 2013年第1期53-56,共4页 West China Journal of Stomatology
基金 教育部大学生创新性实验计划基金资助项目(YA09047)
关键词 鼻咽癌 放射治疗 龋活性 唾液 nasopharyngeal carcinoma radiotherapy caries activity saliva calcium phosphorus
  • 相关文献

参考文献14

  • 1Sun HB, Gao XJ, DengJ, et al. Progress of oral sequelae during head-neck radiotherapy[J]. ChinJ Dent Res, 2010, 13 (I): 51-55.
  • 2Lal P, Bajpai R, Khurana R, et al. Changes in salivary flow rates in head and neck cancer after chemoradiotherapy[J].J Cancer Res Ther, 2010, 6 (4) : 458-462.
  • 3Teshima K, Murakami R, Tomitaka E, et al. Radiation-induced parotid gland changes in oral cancer patients: Correlation between parotid volume and saliva production[J].JpnJ Clin Oncol, 2010, 40 CD : 42-46.
  • 4曾晓娟,梁自民,朱莲娜,关淑妮,卢国泽.鼻咽癌放疗前后口腔致龋菌丛变化的纵向研究[J].现代口腔医学杂志,2001,15(1):37-38. 被引量:5
  • 5刘坤,高宁,王翼川,王昌美,王晓毅,高庆红,宣鸣,温玉明.口腔癌术后放疗患者口腔菌群的变化[J].华西口腔医学杂志,2005,23(2):128-129. 被引量:23
  • 6孙慧斌,高学军,李宁毅,陆海军,邓婧.鼻咽癌患者放疗前后口腔产酸能力的研究[J].现代口腔医学杂志,2007,21(6):575-576. 被引量:3
  • 7杨文东,李雨琴,高学军.放射性龋发病因素的初步研究[J].现代口腔医学杂志,1999,13(1):36-38. 被引量:9
  • 8Gandhy M, Damle SG. Relation of salivary inorganic phosphorus and alkaline phosphatase to the dental caries status in children[J].J Indian Soc Pedod Prev Dent, 2003, 21 (4) : 135-138,.
  • 9Cornejo LS, Brunotto M, Hilas E. Salivary factors associated to the prevalence and increase of dental caries in rural schoolchildren[J]. Rev Saude Publica, 2008, 420): 19-25.
  • 10Jawed M, Shahid SM, Qader SA, et al. Dental caries in diabetes mellitus: Role of salivary flow rate and minerals [J].J Diabetes Complications, 2011, 25 (3) :183-186.

二级参考文献43

  • 1刘坤,高宁,王翼川,王昌美,王晓毅,高庆红,宣鸣,温玉明.口腔癌术后放疗患者口腔菌群的变化[J].华西口腔医学杂志,2005,23(2):128-129. 被引量:23
  • 2何伦中 刘大维 等.成都地区放射性龋病的调查报告[J].实用口腔医学杂志,1988,4(3):138-138.
  • 3崔培芳 李生惠 等.342例鼻咽癌患者放疗后龋病发病情况的调查分析[J].口腔医学,1986,6(1):12-12.
  • 4Hashimoto Y. Vertebral osteomyelitis associated with disseminated candidiasis in an oral cancer patient[J]. J Oral Maxillofacial Surg, 1991,49(8) :901-903.
  • 5Nagy K, Sonkodi I. Microbial study of the surface of malignant tumors of the oral cavity[J]. Fogorv Sz, 1998, 91(8-9):281-284.
  • 6陈谦明 李秉琦.口腔黏膜病学[M].北京:人民卫生出版社,1998.54-87.
  • 7O'Connell AC, Baccaglini L, Fox PC, et al. Safety and efficacy of adenovirus-mediated transfer of the human aquaporin-1 cDNA to irradiated parotid glands of non-human primates. Cancer Gene Ther,1999, 6(6) :505-13.
  • 8Zheng C, Hoque AT, Braddon VR, et al. Evaluation of salivary gland acinar and ductal cell-specific promoters in vivo with recombinant adenoviral vectors. Hum Gene Ther, 2001, 12 ( 18 ) :2215-2223.
  • 9Li J, Zheng C, Zhang X, et al. Developing a convenient large animal model for gene transfer to salivary glands in vivo. J Gene Med, 2004, 6(1):55-63.
  • 10Braddon VR, Chiorini JA, Wang S, et al. Adenoassociated virusmediated transfer of a functional water channel into salivary epithelial cells in vitro and in vivo. Human Gene Ther, 1998, 9( 18 ) :2777-2785.

共引文献59

同被引文献34

引证文献5

二级引证文献19

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部