摘要
目的探讨脾动脉缩窄对大鼠肝硬化进程的影响。方法将96只sD大鼠随机分3组，对照组仅行开腹术；切脾组开腹行脾脏切除术；脾动脉缩窄组开腹行脾动脉缩窄术，然后腹腔注射硫代乙酰胺诱导肝硬化模型。定期处死一定数量的大鼠，动态观察大鼠血常规、肝功能、肝组织病理改变及血清Tuftsin水平变化。结果术后对照组大鼠白细胞、红细胞和血小板逐渐下降（P〈0．05），而切脾组和脾动脉缩窄组未见明显变化（P〉0．05）；切脾组与脾动脉缩窄组的肝功能损伤和肝硬化程度较同期对照组相比轻（P〈0．05）；脾动脉缩窄组血清Tuftsin水平与对照组比较差异无统计学意义（P〉0．05），而切脾组Tuftsin水平显著下降（P〈0．05）。结论脾动脉缩窄术和切脾术均能有效地防止脾功能亢进的发生，从而延缓肝硬化的进展，而脾动脉缩窄术则保留了脾脏的功能。
Objective To study the effect of splenic artery coarctation on liver cirrhosis process in rats and explore the value of splenic artery coarctation. Methods In this study, 96 SD rats were randomized into 3 groups： control group, splenectomy group and splenic artery coarctation group. Liver cirrhosis was induced with intraperitoneal injection of thioacetamide. WBC, RBC, PLT, ALT, Alb, T-Bil, hepatic tissue pathology were evaluated among all groups in different phase. Results WBC, RBC, PLT of rats in control group, gradually decreased after surgery （ P 〈 0. 05 ）, while that in splenectomy group and splenic artery coarctation group did not change significantly （ P 〉 0.05 ）. Liver function and the severity of liver cirrhosis in splenectomy group and splenic artery coarctation group were less compromised（ P 〈 0. 05 ）. Tuftsin level remained about the same in control group and splenic artery coarctation group （ P 〉 0. 05 ）, while decreased significantly in rats of splenectomy group （ P 〈 0. 05 ）. Conclusions Splenic artery coarctation and splcnectomy can prevent hypersplenism and alleviate liver cirrhosis, at the same time splenic artery coarctation reserves the immune function of the spleen.
出处
《中华普通外科杂志》
CSCD
北大核心
2013年第1期45-47,共3页
Chinese Journal of General Surgery
基金
浙江省重中之重“外科学”学科资助项目
浙江省新苗人才计划项目资助（2008R40G2090051）
关键词
肝硬化
脾动脉
脾功能亢进
疾病模型
动物
Liver cirrhosis
Splenic artery
Hypersplenism
Disease models, animal
