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WT1异构体与白血病发生 发展及预后的关系

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摘要 WT1基因作为肿瘤抑制基因参与Wilms瘤的发生。然而.大量研究显示WT1基因作为一种重要的转录调控因子。参与许多肿瘤特别是白血病的发生.其通过两种选择性剪接编码产生四种主要异构体,不同异构体的功能及相互之间的比例与白血病的发生、发展及预后之间的关系逐渐引起人们的关注,本文就此进行综述。
作者 王婕 徐菁
出处 《中国药物与临床》 CAS 2013年第2期187-188,共2页 Chinese Remedies & Clinics
基金 山西省自然科学基金(2010011047-2)
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参考文献17

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