摘要
CD40-CD40配体（CD40．CD40L）交联是体内免疫反应中一条重要的细胞信号传导通路，参与细胞免疫和体液免疫调节。CIM0-CD40L信号传导通路异常可导致机体免疫系统发生紊乱，产生免疫病理反应。儿科多种疾病如免疫缺陷病、某些炎症性疾病和免疫性疾病的发生与CD40-CD40L信号传导通路异常有密切关系。研究CD40-CD40L与这些疾病之间的关系具有重要的临床意义。
CD40-CD40 ligand （CD40-CD40L） cross-linking, an important cell signaling transduction pathway in immune response,is involved in the regulation of cellular and humoral immune. CD40-CD40L signa-ling pathway abnormalities can lead to immune system disorders and incur immune pathological reaction. A vari-ety of common pediatric diseases, such as immunodeficiency diseases, inflammatory diseases and autoimmune diseases,are associated with CD40-CD40L signaling transduction pathway abnormalities. The relationship be-tween CD40-CD40L and the above-mentioned diseases is of clinical significance.
出处
《国际儿科学杂志》
2013年第1期80-83,共4页
International Journal of Pediatrics
基金
山东省自然科学基金项目（ZR2011HM029）
