摘要
目的以了解茂名地区育龄妇女生殖道人乳头瘤病毒(HPV)感染及其亚型分布情况,为该市预防HPV感染和宫颈癌防治提供理论依据。方法用专用宫颈刷取妇女宫颈脱落细胞,应用基因芯片技术同时检测23种HPV亚型。结果 1410例标本中阳性366例,阳性率26.0%,高危感染217例,占感染总数59.3%,高危感染率排在前5位的依次是16型(16.2%)、52型(12.8%)、58型(9.8%)、56和18型(皆为5.1%)。低危感染73例,占感染总数19.9%,主要为11、6、43型。21～40岁的年龄阶段检出率最高,占总阳性数的71.9%。单一基因亚型感染242例,占感染人数的66.1%,双重感染82例,占感染人数的22.4%,三重以上感染42例,占感染人数的11.5%。主要是高危感染,占59.3%,低危感染和高低混合感染比例相当。结论茂名地区妇女HPV感染较高,主要为单一感染,感染亚型主要是16、52、58、56和18型。
Objective To know the situation of women＇s genital HPV infection and the distribution of HPV subtypes in Maom- ing, so as to provide theoretical basis for the prevention of HPV and treatment of cervical cancer. Methods The cervical lost cells were collected by special cervical brush, and 23 varieties of HPV subtypes were simultaneously detected by DNA chip technology. Results Among the samples of 1 410 cases,366 cases were positive,covering 26.0%. The high-danger infection of 217 cases cov- ered 59.3% of the total infection patients. The high-danger infection ratios ranking the top 5 were in turn as follows., type 16（16. 20%）, type 52（12.8%）, type 58（9.8%）, type 56（5. 1%）, and type 18（5.1%）. The low-danger infection of 73 cases covered 19. 9% of the total infection patients, mainly focusing on type 11, type 6 and type 43. The patients with ages from 21 to 40 had the highest detection rate,covering 71.9% of the total positive patients. The sole gene subtype infection of 242 cases covered 66.1% of the total infection patients. The double infection of 82 cases covered 22.4% of the total infection patients. The triple or more infec- tion of 42 cases covered 11.5% of the total infection patients. The infection mainly focused on high-danger infection, covering 59. 3 %. The low-danger infection almost equaled to the high and low mixed infection. Conclusion The women HPV infection rate in Maoming area was hight mainly focusing on single infection. The infection subtypes mostly were type 16, 52, 58, 56 and 18.
出处
《国际检验医学杂志》
CAS
2013年第3期327-328,共2页
International Journal of Laboratory Medicine
基金
广东省荗名市科技计划项目(20102103)
