摘要
创面愈合是机体面对外来损伤因素进行自我保护的病理生理过程.创面愈合过程分为炎症期、修复期和组织重塑期,这3个时期相互重叠,协调促进创面愈合.巨噬细胞是创面愈合过程中的重要细胞,其作用贯穿整个创面修复过程,不但可以吞噬清除坏死组织、病原微生物和异物,而且可以分泌多种细胞因子趋化修复细胞,刺激细胞增殖,促进血管化,加速胶原沉积和肉芽新生.
Macrophages play important roles in all stages of wound healing.Changes in micro-environment leads to transformation of macrophages type Ⅰ and type Ⅱ,thereby playing a role in wound healing.During the early inflammatory phase,type Ⅰ macrophages exert pro-inflammatory function such as antigen-presenting,phagocytosis,and the production of inflammatory cytokines and growth factors.While during the wound healing phase,macrophages were transformed into type Ⅱ,which stimulate the proliferation of fibroblasts,keratinocytes,and endothelial cells by expressing growth factors.This results in the formation of granulation tissue,angiogenesis,and the formation of ECM,so as to promote wound healing.This review summarizes the function and change in phenotype of macrophages in different stages of wound healing.
出处
《中华烧伤杂志》
CAS
CSCD
北大核心
2013年第1期62-64,共3页
Chinese Journal of Burns
