摘要
【目的】制备一种具有良好直肠应用前景的温度敏感性水凝胶(液体栓)。【方法】以黄芩苷(Baicalin,BC)为模型药物,以泊洛沙姆407(PoloxamerF127,P407)为主要凝胶基质,以冷法制备温敏凝胶,以相转变温度为主的多因素为指标,筛选出含药液体栓的最佳处方。进而借助透析袋-浆法以及紫外分光光度法,考察其体外释药性能。【结果】最佳处方为P407-RA-PEG400(18::05:1.0)。该处方,制成的胶凝温度约为35℃,7h内体外释药百分率达92%,含药温敏凝胶相比原料药不论在释药的速度和程度上均有显著优势,说明该剂型更能发挥黄芩苷的速释作用。【结论】制备出了一种更加安全、有效、稳定的载药温敏凝胶,以期为难溶性药物以及中药新剂型的开发做一点新的尝试。
【Objective】To prepare a thermosensitive in situ gel （liquid suppository） for rectal administration and develop a method for the determination of drug release.【Methods】The thermosensitive gel was prepared by Cold Method. The formulation screening was performed by taking sol-gel transition temperature and many other factors. UV and dialysis bag-pulp methods were used for the determination of drug release in vitro.【Results】The best formulation of BC thermosensitive gel was PoloxamerF127- SA-PEG4000 （18：0.5：1.0）. The T gel of the best formulation was 35 ℃. In 7 hours, the drug release in vitro reached 92%. There were some distinct advantages of the thermosensitive in situ gel in the drug release of speed and extent. It indicated that the quick-release of BC was promoted by this type of formulation.【Conclusion】A drug loaded thermosensitive in situ gel is prepared, it is more safe, more effective and more stable.
出处
《武警后勤学院学报（医学版）》
CAS
2012年第12期986-989,共4页
Journal of Logistics University of PAP（Medical Sciences）
关键词
黄芩苷
泊洛沙姆
中药
原位凝胶
液体栓
Baicalin
Poloxamer
chinese medicine
in situ gel
liquid suppository
