摘要
1例47岁女性患者日因发热伴乏力、流涕、咳嗽、咽痛,自行口服对乙酰氨基酚(0.5 g/次)和安乃近(0.25 g/次)治疗,药物服用不规律,每日3～4次,共服用3 d,症状稍缓解。第4天实验室检查:丙氨酸转氨酶(ALT)7247 U/L,天冬氨酸转氨酶(AST)2483 U/L,尿素氮28.3 mmol/L,肌酐630μmol/L,12 h尿量为400 ml。诊断为肝损伤、急性肾衰竭。给予保肝、输注新鲜冰冻血浆、静脉滴注前列腺素E1及持续性肾脏替代治疗。治疗第4天复查,ALT 93 U/L,AST 56 U/L,尿素氮19.1 mmol/L,肌酐166μmol/L,尿量4000 ml/d,患者肝肾功能基本恢复正常。
A 47-year-old female patient self-medicated with paracetamol （0.5 g per time） and metamizole sodium （0.25 g per time） for fever, fatigue, cough, and pharyngalgia. She took the drugs irregularly （3-4 times daily for 3 days） and the patient＇s symptoms were slightly relieved. On day 4, laboratory tests showed the following values ： a lanine transaminase （ALT） 7247 U/L, aspartate transaminase （AST） 2483 U/L, urea nitrogen 28.3 mmol/L, ereatinine 630 μmol/L and 12-hour urinary volume for was 400 ml. Hepatic injury and acute renal failure were diagnosed. The treatments including liver protection, fresh frozen plasma infusion, an IV infusion of prostaglandin El , and continuous renal replacement therapy were given. Four days after treatment, a reexamination showed the following values： ALT 93 U/L, AST 56 U/L, urea nitrogen 19. 1 mmol/L, creatinine 166 μmol/L, urinary volume 4000 ml/d and her hepatic and renal functions basically returned to normal.
出处
《药物不良反应杂志》
2012年第6期387-389,共3页
Adverse Drug Reactions Journal
