摘要
目的对慢性细菌性前列腺炎(CBP)患者前列腺液中的病原菌分布及耐药情况进行分析。方法 875例慢性前列腺炎患者,取前列腺液做细菌培养,采用全自动微生物分析系统Phoenix 100进行菌种鉴定及药物敏感试验。对经前列腺液培养证实为CBP的数据进行分析。结果875例标本,经前列腺液细菌培养阳性证实的CBP患者共629例。病原菌中革兰阳性细菌所占比例(584株,92.9%)明显高于革兰阴性细菌(45株,7.1%)。共分离出37个菌种,主要为溶血性葡萄球菌265株(42.1%)、表皮葡萄球菌127株(20.9%)、粪肠球菌35株(5.0%)。对抗生素的耐药性较高,且呈多重耐药。结论临床CBP以革兰阳性球菌感染为主,抗菌谱复杂,应对每一个CBP患者进行正确的病原体评估,根据药物体外敏感试验,选择合适以及个性化的抗生素治疗方案。
Objective To analyse the flora distribution and drug resistance of prostate fluid in patients with chronic bacterial prostatitis（CBP）. Methods 885 patients with CBP were examined. Bacterial aerobic culture and drug-susceptibility test were performed using automatic bacterial analysis system. The analysis has been restricted only to patients with laboratory-confirmed diagnosis of CBP. Results Of the 875 cases, 629 CBP cases were confirmed by prostatic fluid bacterial culture-positive. The proportion of Gram-positive bacteria （584, 92.9%） higher than Gram-negative bacteria （45, 7.1%）. There were 37 species found, mainly were Staphylococcus haemolyticus（42.1%）, Staphylococcus epidermidis（20.9%） and Enterococcus faecalis（5.0%）. They were high resistance to antibiotics, and showed multiple drug resistance. Conclusions The pathogens associated with CBP were mainly the Gram-positive bacteria. Because of the complex antimicrobial spectrum, we should assess correctly of the pathogen to each CBP patient according to the results of in vitro drug sensitivity test and select the appropriate antibiotic treatment and personalized program.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2013年第2期I0004-I0006,共3页
Chinese Journal of Antibiotics
