摘要
目的 对地塞米松及葡萄糖酸钙联合缩宫素预防剖宫产产后出血的有效性及安全性进行探讨。方法 128例足月剖宫产产妇随机分为对照组与观察组,其中观察组又分A、B、C三组。所有产妇均于胎儿娩出后宫体注射20 u缩宫素。观察组加用：A组：切皮前10-15 min内静脉滴注晶体液100 ml＋10%葡萄糖酸钙10 ml;B组：胎儿娩出后静脉注射地塞米松10 mg;C组：切皮前10-15 min内静脉滴注晶体液100 ml＋10%葡萄糖酸钙10 ml,胎儿娩出后静脉注射地塞米松10 mg。对照组不予上述药物进行治疗,仅于胎儿娩出后宫体注射20 u缩宫素。对比观察组与对照组在术中与术后24 h的总出血量、药物不良反应及其他症状。结果 观察组A、B、C三组的出血量分别为（286.8±52.7）ml、（301.8±60.9）ml、（277.3±44.5）ml,对照组出血量为（422.9±78.2）ml,观察组与对照组差异均有统计学意义（t=－0.699、0.481、－0.407,均P〈0.01）,A、B、C三组之间差异无统计学意义（P〉0.05）,且两组均未出现药物不良反应及其他症状。结论 地塞米松及葡萄糖酸钙联合缩宫素预防产后出血有效性及安全性高,且方法简便,值得推广。
Objective To discuss the safety and effectiveness of dexamethasone and calcium gluconate combined with oxytocin to prevent postpartum hemorrhage.Methods 128 maternal patients with full-term delivery were divided the patients into two parts randomly：the control group and the observation group,of which contained three groups（A,B,C）.The patients were all given 20u oxytocin.As to observation,group A：before 10-15min of cutting skin,give 10mg of dexamethasone and 10ml 10%calcium gluconate rapid intravenous infusion,group B：give 10mg intravenous infusion of dexamethasone after babies were boro,group C：before 10~15min of cutting skin,give 10mg of dexamethasone and 10ml 10%calcium gluconate rapid intravenous infusion and then give 10mg dexamethasone after babies were born.The control group wasn′t given that medicine,and only give them 20u oxytocin when babies were born.At last,give contrast of total amount of bleeding,ill reflecting of medicine and the other symptom after 24h.Results The amount of bleeding of observation group A,B,C were（277.3±44.5）ml,（286.8±52.7）ml,（301.8±60.9）ml,respectively.The amount of bleeding of the control group was（422.9±78.2）ml.The observation group and control group had significant differences（t=-0.699,0.481,-0.407,all P〈0.01）,and there was no significant difference between group A,B,and C（P〉0.05）.And this two groups had no bad reflection and the other symptoms. Conclusion Dexamethasone and calcium gluconate combined with oxytocin to prevent postpartum hemorrhage has great efficacy and safety.This method must be extended.
出处
《中国基层医药》
CAS
2013年第1期5-6,共2页
Chinese Journal of Primary Medicine and Pharmacy
关键词
地塞米松
葡萄糖酸钙
缩宫素
产后出血
剖宫产术
Dexamethasone
Calcium gluconate
Oxytocin
Postpartum hemorrhage
Cesarean
