摘要
目的调查我院流浪精神分裂症患者抗精神病药物使用的性别差异。方法采用一日法,以2012年2月18日为时间节点,对我院流浪精神分裂症住院患者(男159例,女111例)的治疗情况进行对比研究。结果①单一使用抗精神病药物:占首位(男性为57.2%,女性为79.3%);联用两种以上抗精神病药物者男性为42.8%,女性为20.7%,男性明显多于女性,差异有统计学意义(P<0.001)。②男性使用抗精神病药物排在前3位的是:利培酮,氯丙嗪,舒必利;女性使用抗精神病药物排在前3位的是:利培酮,氯氮平,氯丙嗪;无重大剂量用药者。③抗精神病药物日均剂量折算为氯丙嗪剂量后,男性与女性比较差异无统计学意义(P>0.05)。结论本调查提示,目前,我院流浪精神分裂症患者抗精神病药物的使用情况比较规范合理,在联合用药方面及部分药物使用频度方面存在性别差异,日均剂量方面性别差异无统计学意义。
Objective To explore the gender difference on antipsychotic drug use patterns for vagrant mental patients with schizophrenia. Methods Based on the investigation from February 18th in 2012, the treatment for 159 male and 111 female vagrant mental patients with schizophrenia was studied. Results ①The majority medication method was signle drug use （male：57.2% , female：79.3% ） ; the rest of patients were treated with 2 or more than 2 types of antipsychotics （male ：42. 8 % , female：20. 7% ） , there was significant differences between male and female （P 〈 0. 001 ）. ②Antipsychotic medication most frequently prescribed was risperidone, chlorpromazine, sulpiride in male; while risperidone,clozapine,chlorpromazine in female; and there was no mega dose patients. ③The average of daily dose in antipsychotic medication for male had no significant difference with female if it was converted into the dose of chlorpromazine（ P 〉 0. 05 ）. Conclusion It is relatively canonical and reasonable for the usage condition of antipsy-chotic drug in vagrant mental patients with schizophrenia in our hospital, the usage frequency of singleL/combination drug use is different between male and female,and it＇s not obvious for the average of daily dose in sexuality.
出处
《实用药物与临床》
CAS
2013年第1期52-54,共3页
Practical Pharmacy and Clinical Remedies
关键词
流浪精神分裂症患者
抗精神病药物
性别差异
Vagrant mental patients with schizophrenia
Antipsychotic drug
Gender difference
