摘要
目的建立米格列醇片含量测定的高效液相色谱法。方法采用氨丙基键合硅胶色谱柱(4.6 mm×250mm,5μm),以0.025 mol.L-1磷酸二氢钾溶液-乙腈(30∶70)为流动相;流速1.0 mL.min-1;柱温40℃;检测波长为210 nm。结果线性范围为0.2～0.6 mg.mL-1,r=0.999 7;平均回收率为100.6%,RSD为1.7%(n=9)。结论本法专属性强、准确度好、简便、快速。
Objective To establish an HPLC method for the determination of Miglitol Tablets. Methods Aminopropyl - bonded silica gel column （4.6 mm × 250 mm, 5 μm） was adopted with 0. 025 mol· L- 1 potassium dihydrogen phosphate solution - acetonitrile （30：70） as mobile phase. The flow rate was 1.0 mL· min- 1, the column temperature was 40 ℃ and the detection wavelength was 210 nm. Results The linear range was 0.2 · 0.6mg· mL- 1 （ r = 0. 999 7 ） , the average re- covery was 100.6% and the RSD was 1.7% （ n = 9 ）. Conclusion The method was specific, accurate, convenient and rap- id.
出处
《药学研究》
CAS
2013年第1期27-28,共2页
Journal of Pharmaceutical Research
