摘要
目的探讨胎膜早破发生后抗生素使用时间与分娩结局之间的关系及抗生素使用对分娩结局的影响。方法选取住院分娩的474例胎膜早破产妇作为研究对象，根据胎膜早破时间分组，其中在破水后12h之内者分为A组，共284例，随机分为A1组与A2组，分别为142例；在破水后12～24h之内者为B组，共120例；破水后24h后者为C组，共70例。A2组、B组、C组均给与抗生素静脉滴注，A1组不给予静脉滴注，观察妊娠结局。结果B组与A组、C组与A组分娩方式、胎儿宫内窘迫、新生儿窒息、绒毛膜羊膜炎发生率差异均有统计学意义（均P〈0．05）；A2组与A1组分娩方式、胎儿宫内窘迫、新生儿窒息、绒毛膜羊膜炎发生率差异均无统计学意义（均P〉0．05）。结论破水12h之内产妇如无明确证据证明有感染的情况下可以不使用抗生素，是否使用抗生素并不影响分娩结局。
Objective To explore the relationship between antibiotic application time and delivery outcome after the premature rupture of membranes, and to explore the effect of using antibiotics to delivery outcome. Methods 474 premature rupture of fetal membranes parturient who deliver in our desk work were selected as study objects. According to the time of premature rupture of membranes ,the patients were dividwd into groups. The patients that bear children within 12h after the membrane rupture are divided into A group. A group had 284 cases and they were randomly divided into two groups,A1 group and A2 group,both of which had 142 cases. The patients that beared children within 12 - 24h after the membrane rupture were divided into B group. B group had 120 cases. The patients that beared children 24h after the membrane rupture were divided into C group. C group had 70 cases. A2 group, B group and C group were all given antibiotic intravenous infusion,A1 group was not given that. The pregnancy outcome was observed. Results B group and A group, C group and A group had significant differences in the mode of deliver- y,fetal distress,neonatal asphyxia,chorioamnionitis incidence（all P 〈 0.05 ）. A2 group and A1 group had no signifi- cant differences in the mode of delivery, fetal distress, neonatal asphyxia, chorioamnionitis incidence （ all P 〉 0.05 ）. Conclusion If there are clear evidence which can prove maternal have infected within 12h after the membrane rupture ,we can choose not to use antibiotics. And whether using antibiotics or not can not affect the delivery outcome.
出处
《中国基层医药》
CAS
2013年第2期223-224,共2页
Chinese Journal of Primary Medicine and Pharmacy
关键词
胎膜早破
分娩结局
抗生素
Premature rupture of membranes
Delivery outcome
Antibiotics
