摘要
硫氧还蛋白相关蛋白14（TRP14）是一种新发现的硫氧还蛋白（Trx）家族二硫还原酶，具有保守的CPDC模序。其结构和功能既与1h家族代表性成员nx具有相似性，又有诸多不同。当肿瘤坏死因子-a（TNF-a）诱导细胞产生活性氧时，TRP14可作为细胞内氧化还原状态的感受器，改变其作用底物动力蛋白轻链的氧化状态，从而调控TNF-a诱导的转录核因子-KB（NF·KB）信号途径、丝裂原活化的蛋白激酶信号途径和凋亡信号途径。
Thioredoxin-related protein 14 （TRP14）, a new member of Trx family, is a novel disulfide reductase with conservative CPDC motif. Its structure and function are comparable to Trx, which is the representative member of Trx family. However, there are many differences. When tumor necrosis factor-a （TNF-a） induced cells to produce the active oxygen, TRP14 can change oxidatin state of dynein light chain （ its substrate ）, act as a sensor of the intracellular redox state to regulate NF-KB signaling pathways induced by TNF-a, MAPK and apoptosis signaling pathways.
出处
《国际肿瘤学杂志》
CAS
2013年第2期86-89,共4页
Journal of International Oncology
基金
国家自然科学基金（81072119）
