摘要
[目的]观察EZH2和P27蛋白在前列腺癌组织中的表达,分析两者与前列腺癌的病理分级、临床分期之间的关系,探讨EZH2和P27蛋白在前列腺癌临床诊断和评估预后的意义.[方法]选择自2007年1月至2011年12月间接受手术的前列腺癌30例和前列腺增生17例的病理组织标本.采用免疫组织化学二步法检测前列腺癌及前列腺增生组织中EZH2和P27蛋白的表达情况,分析其与病理分级、临床分级之间的关系.[结果]EZH2蛋白表达:在前列腺癌组中及前列腺增生组中的表达阳性率分别为86.7%(26/30),41.2%(7/17),相比较差异具有统计学意义(P<0.05);在前列腺癌高、中分化组与低分化组之间和高中、低分化临床分期之间差异均具有统计学意义(P<0.05).P27蛋白表达:在前列腺癌组中及前列腺增生组中的表达阳性率分别为40.0%(12/30),76.5%(13/17),相比较差异具有统计学意义(P<0.05);P27蛋白的阳性率与前列腺癌组织的病理分级呈负相关.[结论]EZH2和P27蛋白表达检测对于前列腺癌的诊断、疾病进展及预后的判断具有重要的意义.
OBJECTIVE To analyze the expression of EZH2 and P27 in benign prostatic hyperplasia（BPH） and prostate carcinoma （PCa） and their correlation with clinical stage and pathological grade to discuss its significance of clinical diagnosis and assessment of prognosis for PCa. METHODS 30 tissue specimens of PCa and 17 tissue specimens of BPH were selected from January 2007 and December 2011, and the expression of EZH2 and P27 in BPH and PCa was detected by two steps of immunohistochemistry to analyze the relationship between both positive expression and clinical stage, pathological grade. RESULTS Expression rate of EZH2 was 86.7% （26/30） in PCa and 41.2% （7/17） in BPH, and the differences were statistically significant （P %0.05） between expression rates, between high-, moderate- and low-differentiation of pathological grade, and between high- and low- clinical stage. Expression rate of P27 was 40. 0% （12/30） in PCa and 76.5% （13/17） in BPH, and the differences were statistically significant （P〈0.05）, and the expression rate of P27 was negative correlation with pathological grade of PCa. CONCLUSION EZH2 and P27 have significance for diagnosis, development and evaluating prognosis of PCa.
出处
《延边大学医学学报》
CAS
2012年第4期272-276,共5页
Journal of Medical Science Yanbian University
