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STAT3在大肠癌中的表达及其临床意义 被引量：7

Expression and clinical significance of STAT3 in colorectal carcinoma
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摘要 目的探讨信号转导子与转录活化子3(STAT3)在大肠癌组织中的表达,及其与临床病理因素间的关系。方法应用免疫组织化学S-P方法检测STAT3在50例大肠癌组织中的表达情况。结果 STAT3蛋白在大肠癌组织中的阳性表达率分别是68%(34/50)明显高于大肠正常黏膜组织35%(7/20)。STAT3蛋白表达与淋巴结转移及临床Duke’s分期有关,与患者年龄、性别及肿瘤分化程度、浸润深度无关。结论 STAT3在大肠癌的发生发展中具有重要作用。 Objective To investigate the expression and clinical significance of STAT3 in colorectal carcinoma（CRC）.Methods Immunohistochemical staining（S-P method） for STAT3 protein was performed in 50 CRC.Results The positive rates of STAT3 in CRC（64.5%） were higher than those in normal mucosa（35%）（P0.05）.The expression of STAT3 protein was correlated with lymphnode metastasis and Dukes stage.Conclusion STAT3 protein plays an important role in the carcinogenesis of CRC.
作者 张国强 曹立宇
机构地区 安徽省太和县中医院病理科 安徽医科大学病理学教研室
出处 《安徽医药》 CAS 2012年第10期1442-1443,共2页 Anhui Medical and Pharmaceutical Journal
基金 安徽省自然科学基金面上项目(No 090413098) 安徽省高等学校省级自然科学研究重点项目(No KJ2009A76)
关键词 大肠癌 STAT3 免疫组织化学 colorectal carcinoma STAT3 immunohistochemistry
分类号 R735.34 [医药卫生—肿瘤]
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参考文献12

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二级参考文献11

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安徽医药
2012年 第10期

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