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36例慢性丙型肝炎抗病毒副作用及对策 被引量:5

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摘要 从1989年克隆HCV病毒以来[1],目前全球约有1.8亿人感染HCV,其中,20%-30%发生肝硬化和肝衰竭,2%-5%发生肝细胞癌(HCC)[2]。我国约有1000万HCV感染者,相关HCC年死亡率为23.5/10万人。丙肝病毒(HCV)是造成慢性肝炎、肝硬化及肝癌的重要原因之一。对丙型肝炎治疗的研究不断进展。目前丙型肝炎抗病毒治疗的标准方案是干扰素(IFN)联合利巴韦林(RBV)治疗。抗病毒治疗存在一定不良反应,影响疗效。本研究对36例进行抗病毒治疗的慢性丙型肝炎患者副作用进行了研究。
出处 《中国实验诊断学》 2013年第2期346-347,共2页 Chinese Journal of Laboratory Diagnosis
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  • 1Choo QL,Kuo G,Weiner AL et al. Isolation of a cDNA clone de- rived from a blood-borne non-A, non-B viral hepatitis genome[J]. Science, 1989,244(4902) : 359.
  • 2Lavanchy D. The global burden of hepatitis C [J]. Liver Int, 2009,29 (Suppll) : 74.
  • 3Bacon BR,Khalid O. New therapies for hepatitis C virus infection [J]. Mo Med,2011,108(4) :255.
  • 4饶慧瑛,魏来.慢性丙型肝炎直接抗病毒药物的研究进展和应用前景[J].传染病信息,2012,25(2):83-86. 被引量:8
  • 5Vezali E, Aghemo A, Colombo M. A review of the treatment of chronic hepatitis c virus infection in cirrhosis [J]. Clin Ther, 2010,32(13) :2117.

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  • 1陆再英,钟南山.内科学[M].第7版.北京:人民卫生出版社.2008:251.
  • 2Tarantino G, Gngliardi G, Conea P. Do thyroid abnormalities detected in patients treated for HCV-related chronic hepatitis persist[J]. International Journal of Immunopathology and Pharmaco logy,2011,21(1) :453-454.
  • 3Su YY, Liu HX, Wang N China: a systematic review Hepatitis C virus genotypes in [J]. Zhonghua Liu Xing BingXue Za Zhi, 2013, 34 (1): 80-84.
  • 4Naderi M, Gholiopour N, Zolfaqhari MR, et al. Hepatitis C virus and vaeeine development [J]. Int J Mol Cell Med, 2014, 3 (4): 207-215.
  • 5Aqnesod D, De Nieolo A, Simiele M, et al. Development and validation of a useful UPLC-MS/MS method for quantification of total and phosphorylatedribavirin in peripheral blood mononuelear cells of HCV+ patients [J]. Pharm Biomed Anal, 2014, 90 (5): 119-126.
  • 6Hirakawa M, Ikeda K, Arase Y, et al. Hepatocarcinogenesis following HCV RNA eradication by interferon in chronic hepatitis patients [J]. Int Med (Tokyo, Japan), 2007, 47 (19): 1637-1643.
  • 7Ferndndez-Rodriguez CM, Alonso S, Martinez SM, et al. Peginterferon plus ribavirin and sustained virological response in HCV-related cirrhosis: outcomes and factors predicting response [J]. Ame J Gastroenterol, 2010, 105 (10): 2164-2172.
  • 8Oze T, Hiramatsu N, Yakushijin T, et al. Pegylated interferon alpha-2b (Peg-IFN a-2b) affects early virologic response dose - dependently in patients with chronic hepatitis C genotype 1 during treatment with Peg-IFN a-2b plus ribavirin [JT. Viral Hepatitis, 2009, 16 (8): 578-585.
  • 9GanserA, Carlo-Stella C, Greher J, et al. Effect of recombinant interferons alpha and gamma on human bone marrow-derived megakaryoeytic progenitor cells [J]. Blood, 1987, 70 (4): 1173-1179.
  • 10Liu YL, Du XF, Chen XY, et al. Bone marrow suppression or active proliferation? An analysis of neutropenia after pegylated interferon treatment of patients with chronic hepatitis C [J]. Scand J Infect Dis, 2013, 45 (12): 939- 943.

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