摘要
目的:观察H型高血压患者血清同型半胱氨酸(homocysteine,Hcy)、单核趋化蛋白-1(MCP-1)及白细胞介素-8(IL-8)浓度的变化,并分析Hcy与MCP-1、IL-8之间的相关性。方法:选择佳木斯大学附属第一医院门诊及住院H型高血压患者30例(1组),非H型高血压患者30例(2组),与体检健康者作为正常对照组30例(3组),对3组人群均行Hcy、MCP-1、IL-8水平的测定,并分析H型高血压患者Hcy与MCP-1、IL-8之间的相关性。结果:H型高血压组Hcy、MCP-1、IL-8水平均显著高于非H型高血压组,分别为〔(16.89±2.14)μmol/L vs(8.30±1.43)μmol/L〕(P<0.01)、〔(20.26±3.07)pg/mLvs(13.04±2.30)pg/mL〕(P<0.01)、〔(92.72±9.58)pg/mL vs(77.53±9.26)pg/mL〕,二组均明显高于对照组〔(7.33±1.93)μmol/L〕(分别为P<0.01;P<0.05)、〔(10.88±3.77)pg/mL〕(P<0.01)、〔(66.89±10.23)pg/mL〕(P<0.01),相关分析表明Hcy与MCP-1、IL-8分别呈正相关,相关系数分别为r=0.740,r=0.668(P<0.01)。结论:MCP-1、IL-8在H型高血压中表达明显升高,且Hcy与MCP-1、IL-8分别呈正相关,它们可能参与动脉粥样硬化的发生发展。
Objective：To investigate the changes in the serum level of MCP--1 and IL--8 in patients with H--type hypertension, and their relationship with Hcy. Methods： 30 patients with H--type hypertension and 30 with non-H-type hypertension were enrolled in this study, with another 30 healthy volunteers as the con- trol group; all the subjects were selected from First Affiliated Hospital of Jiamusi University. The blood levels of Hcy, MCP-1, and IL-8 of all the subjects were tested, and the data of the three groups were compared so as to investigate the correlation between Hcy,MCP-1 and IL-8. Results：The H--type hypertensive patients showed significantly higher Hcy, MCP--1 and IL- 8 levels than the non--H-type hypertensive patients [（16.89±2. 14）μmol/L vs （8. 30±1. 43）μmol/L] （P （0.01）, [（20. 26＋3. 07）pg/mL vs （13. 04±2.30）pg/mL] （P （ 0. 01）, [（92.72±9.58）pg/mL vs （77.53± 9.26）pg/mL, the levels of both groups were higher than that of the control group[（7.33±1.93）μmol/L] （P〈 0.01 ;P （ 0.05, respectively）, [（10.88±3.77）pg/mL] （P〈 0.01）, [（66.89±10.23）pg/mL] （P （0.01）, and MCP-1,IL-8 were positively cor-related with Hcy （r = 0. 740, r =0. 668, respectively, P 〈 0.01）. Conclusion：MCP-1,IL--8 were signifi- cantly elevated in H-type hypertension, and MCP-1,IL-8 were positively correlated with Hcy, which may take part in the 15rogress of the atherosclerosis.
出处
《黑龙江医药科学》
2013年第1期5-6,共2页
Heilongjiang Medicine and Pharmacy
