期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

炎症性肠病病因研究进展 被引量：12

下载PDF
导出
摘要 炎症性肠病是在环境、遗传、感染和免疫等多因素相互作用下,肠道黏膜免疫系统异常反应所导致的炎性反应。新近的研究发现,易感基因、维生素以及一些特殊的菌群如难辨性梭状芽孢杆菌等重要因素参与了该病的发病过程,并在两种类型的炎症性肠病(克罗恩病和溃疡性结肠炎)中表现出一定的差异,从而导致不同的发病机制和病理表现,并可能与疾病的转归有关。
作者 樊星 翁谢川 丁日高
机构地区 军事医学科学院毒物药物研究所 军事医学科学院基础医学研究所神经生物学研究室
出处 《国际消化病杂志》 CAS 2013年第1期6-8,16,共4页 International Journal of Digestive Diseases
基金 "重大新药创制"科技重大专项(2012ZX09301-003-008) 国家自然基金青年科学基金项目(No.30500620 No.81001254)
关键词 炎症性肠病 易感基因 难辨性梭状芽孢杆菌 维生素D
分类号 R574 [医药卫生—消化系统]
  • 相关文献

参考文献23

  • 1Voss E,Wehkamp J,Wehkamp K. NOD2/CARD15 mediates induction of the antimicrobial peptide human beta-defensin 2[J].Journal of Biological Chemistry,2006.2005-2011.
  • 2Wang TT,Dabbas B,Laperriere D. Direct and indirect induction by 1,25 dihydroxyvitamin D3 of the NOD2/CARD15-defensin beta2 innate immune pathway defective in Crohn disease[J].Journal of Biological Chemistry,2010.2227-2231.
  • 3Xavier R J,Podolsky DK. Unraveling the pathogenesis of inflammatory bowel disease[J].Nature,2007.427-434.
  • 4Mahurkar S,Banerjee R,Rani VS. Common variants in NOD2 and IL23R are not associated with inflammatory bowel disease in Indians[J].Journal of Gastroenterology and Hepatology,2011.694-699.
  • 5López-Hernández R,Valdés M,Lucas D. Association analysis of MICA gene polymorphism and MICA-129 dimorphism with inflammatory bowel disease susceptibility in a Spanish population[J].Human Immunology,2010.512-514.
  • 6Li Y,Xia B,Lv M. MICB0106 gene polymorphism is associated with ulcerative colitis in central China[J].International Journal of Colorectal Disease,2010.153-159.
  • 7Fan W,Maoqing W,Wangyang C. Relationship between the polymorphism of tumor necrosis factor-α-308 G 》 A and susceptibility to inflammatory bowel diseases and colorectal cancer:a meta-analysis[J].European Journal of Human Genetics,2011.432-437.
  • 8Mittal RD,Manchanda PK,Bid HK. Analysis of polymorphisms of tumor necrosis factor-alpha and polymorphic xenobiotic metabolizing enzymes in inflammatory bowel disease:study from northern India[J].Journal of Gastroenterology and Hepatology,2007.920-924.
  • 9Castellarin M,Warren RL,Freeman JD. Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma[J].Genome Research,2012.299-306.
  • 10Antonelli E,Baldoni M,Giovenali P. Intestinal superinfections in patients with inflammatory bowel diseases[J].J Crohns Colitis,2012.154-159.

同被引文献164

  • 1Stephen J Halpin,P John Hamlin,Daniel P Gree,Lisa Warren,Alexander C Ford.Efficacy of infliximab in acute severe ulcerative colitis:A single-centre experience[J].World Journal of Gastroenterology,2013,19(7):1091-1097. 被引量：1
  • 2Prideaux L, Kamm MA, De Cruz PP, et al. Inflammatory bowel disease in Asia: a systematic review. J Gastroenterol Hepatol, 2012, 27:1266- 1280.
  • 3Montgomery SM, Ekbom A. Epidemiology of inflammatory bowel disease. Curr Opin Gastroenterol, 2002, 18: 416-420.
  • 4Cohen AB, Lee D, Long MD, et al. Dietary patterns and self- reported associations of diet with symptoms of inflammatory bowel disease. Dig Dis Sci, 2013, 58: 1322-1328.
  • 5Mishkin S. Dairy sensitivity, lactose malabsorption, and elimination diets in inflammatory bowel disease. Am J Clin Nutr, 1997, 65: 564-567.
  • 6Cashman KD, Shanahan F. Is nutrition an aetiologieal factor for inflammatory bowel disease? Eur J Gastroenterol Hepatol, 2003, 15: 607-613.
  • 7Reif S, Klein I, Lubin F, et al. Pre-illness dietary factors in inflammatory bowel disease. Gut, 1997, 40:754- 760.
  • 8Zallot C, Quilliot D, Chevaux JB, et al. Dietary beliefs and behavior among inflammatory bowel disease patients. Inflamm Bowel Dis, 2013, 19: 66-72.
  • 9Sousa Guerreiro C, Cravo M, Costa AR, et al. A comprehensive approach to evaluate nutritional status in Crohn's patients in the era of biologic therapy: a case control study. Am J Gastroenterol, 2007, 102:2551- 2556.
  • 10Hancock L, Mortensen NJ. How often do IBD patients require resection of their intestine?[J]. Inflamm Bowel Dis, 2008, 14(Suppl 2): S68-S69.

引证文献12

二级引证文献46

国际消化病杂志
2013年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部