摘要
目的探讨血清尿酸水平与高血压及高血压前期的关系。方法以天津大港油田常住居民为研究对象,调查吸烟、饮酒、家族史等情况,测量血压、体质量及腰围,检测血糖、血脂和尿酸等指标。采用单因素和多因素分析方法,进行血尿酸与血压水平、高血压及高血压前期的相关性分析。结果高血压组、高血压前期组、血压正常组的尿酸水平依次为331(273～389)、288(237～351)、240(202～293)μmol/L,3组间差异有统计学意义(P=0.000)。尿酸水平处于第1、2、3、4分位者其收缩压分别为(120.8±15.7)、(123.6±14.6)、(125.1±14.6)、(129.4±15.8)mmHg,舒张压分别为(78.0±11.0)、(79.8±10.3)、(80.5±10.3)、(83.6±11.1)mmHg。随尿酸水平升高,患高血压前期和高血压的危险也升高,存在剂量—反应关系。与尿酸水平处于最低四分位者相比,调整了多因素后最高四分位者患高血压和高血压前期的危险比分别为3.393(95%CI 2.192～5.252)、1.974(95%CI1.419～2.748)。结论高尿酸水平是高血压和高血压前期的独立危险因素。
Objective To investigate the relationship between serum uric acid and hypertension and pre-hypertension among community residents.Methods A total of 3 416 community residents aged ≥20 years who lived in Dagang oil field of Tianjin city were researched.Some factors such as cigarette smoking,alcohol intake,family history of hypertension were investigated,blood pressure,body weight and waist circumference（WC） were measured,and blood glucose,lipid,uric acid were tested.The associations between uric acid and hypertension and pre-hypertension were analyzed by using univariate and multivariate analysis.Results The mean level of serum uric acid was 331（273-389）,288（237-351）,240（202-293） μmol/L in hypertensives,pre-hypertensives and normotensives,respectively,with a significant difference among the three groups（P=0.000）.The mean level of systolic/diastolic blood pressure was（120.8±15.7）/（78.0±11.0）,（123.6±14.6）/（79.8±10.3）,（125.1±14.6）/（80.5±10.3）,（129.4±15.8）/（83.6±11.1） mmHg for those with uric acid level in the first,second,third and fourth quartile,respectively.The risks of hypertension and pre-hypertension increased with increasing uric acid levels.Furthermore,there were dose-response relationships between uric acid and risks of hypertension and pre-hypertension.Adjusted odds ratio（95%CI） of hypertension and pre-hypertension in the highest quartile of uric acid were 3.393（2.192-5.252）,1.974（1.419-2.748）,respectively,with the lowest quartile as a reference.Conclusion Hyperuricemia is independently associated with both hypertension and pre-hypertension among community residents.
出处
《山东医药》
CAS
2012年第48期35-37,共3页
Shandong Medical Journal
关键词
尿酸
高血压
高血压前期
流行病学
血脂代谢异常
serum uric acid
hypertension
pre-hypertension
epidemiology
abnormality of lipid metabolism
