摘要
目的:研究甲状腺疾病(Thyroid disease)甲状腺自身抗体的临床特点及其在不同甲状腺疾病中的分布状况。方法:运用化学发光免疫法测定1027例门诊及住院病人的血清三碘甲腺原氨酸(T3),甲状腺素(T4),游离三碘甲腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)。根据以上测定结果再结合临床症状分成甲状腺功能亢进、甲状腺功能低下及对照组3组,对照组为经临床治疗甲状腺功能恢复正常的病人及甲状腺激素测定正常的门诊病人。采用化学发光免疫法测定3组病人的甲状腺球蛋白抗体(TGAb)和甲状腺过氧化物酶抗体(TPoAb),分析各种抗体的临床特点以及与临床指标间的关系。结果:甲状腺疾病发病率女性显著高于男性(P<0.05),各组TGAb在男女之间有显著性差异,TPoAb只在对照组的男女之间有显著性差异。甲状腺自身抗体滴度及阳性率在甲亢组和甲减组显著高于对照组。甲减组TGAb显著高于甲亢组。结论:甲状腺功能异常与自身抗体相关,甲减组自身抗体阳性率最高,尤其是TGAb与TPoAb均阳性者,抗体滴度也最高;甲亢组次之;在甲状腺功能已恢复正常的对照组中阳性率与滴度均最低。TGAb的滴度对于甲状腺功能变化有预示作用,发病以女性多见,出现自身抗体者也多见于女性。
Objective：To study the chnical feature of thyroid autoantibodies and their distribution in different thyroid disease.Methods： Serum T3, T4, FT3, FT4, TSH were determined in 1027cases by chemiluminescence immunometric assay including daily and clinical patients.According to the results an clinical syndrome,we divided it into hyperthyroidism, hypothroidism and controls.Controls are patients with thyroid function restored to normal in clinical and daily patients with normal level of thyroid hormones. TGAb and TPoAb were determined in 3 groups by the same method then to analyses their relationship and clinical feature.Result： The disease rate in patients with thyroid disorder is higher in female than in male（P〈0.05 ）.Serum levels of TGAb existed differences between female and male in three groups.Serum levels of TPoAb only existed difference between female and male in controls.Serum levels and positive rate of thyroid autoantibodies are higher in hyperthyroidism and hypothroidism than controls.Serum levels of TGAb is higher in hypothroidism than in hyperthyroidism.Conclusion：Disorder of thyroid function has some relationship with autoantibodies, hypothroidism has the highest positive rate and serum levels, especially both TGAb and TPoAb are positive;hyperthyroidism is the second;the controls with thyroid function has restored to normal has the lowest positive rate and serum levels.Serum levels of TGAb can foresee the changes of thyroid function,positive rate and autoantibodies is higher in female than in male.
出处
《内蒙古中医药》
2012年第23期93-95,共3页
Inner Mongolia Journal of Traditional Chinese Medicine
