摘要
目的:探讨20%吡拉西坦注射液治疗颅内肿瘤术后高颅内压临床疗效和安全性。方法:选择2009年4月～2012年4月在我院神经外科住院治疗的136例颅内肿瘤术后高颅内压患者为研究对象,随机将其分为对照和实验组,对照组患者给予20%甘露醇快速静脉滴注治疗,而实验组患者则给予20%吡拉西坦快速静脉滴注治疗,比较两组患者临床疗效和不良反应发生情况。结果:实验组患者的治疗总有效率(95.59%)明显高于对照组的(85.29%),差异有显著性(P<0.05),且对照组和实验组患者在不良反应发生率方面差异无显著性(P>0.05)。结论:20%吡拉西坦注射液治疗颅内肿瘤术后高颅内压临床疗效确切,降颅压疗效好,安全可靠,不良反应少。
Objective： To investigatetheclinicalefficacyandsafetyofpatientswithhighintracranialpressureafterintracranialtumor surgery by piracetam.Methods： The clinical data of one hundred and thirty-six patients with high intracranial pressure after intracranial tumor surgery who were treated in the department of neurosurgery in our hospital from April 2009 to April 2012 were collected,then patients were divided into the control group and observation group randomly,patients in the control group was given 20% mannitol,but patients in the observation group was given 20% piracetam,the clinical efficacy and adverse reaction of the two groups was evaluated.Results： The total efficient rate was higher in the observation group than that in the control group（95.59%vs 85.29%,P0.05）,but the adverse reaction rate had no difference between the two groups（P0.05）.Conclusion： 20% piracetam can obtain satisfactory curative effect for patients with high intracranial pressure after intracranial tumor surgery,and it is safe,reliable.
出处
《现代生物医学进展》
CAS
2012年第35期6898-6900,共3页
Progress in Modern Biomedicine
关键词
甘露醇
吡拉西坦
颅内肿瘤
颅内高压
临床疗效
Mannitol
Piracetam
Intracranial neoplasm
High intracranial pressure
Clinical efficacy
