摘要
目的:探讨原发性肝癌患者血清甲胎蛋白(AFP)、а-L岩藻糖苷酶(AFU)、β2-微球蛋白(β2-MG)、糖类抗原-199(CA199)的含量及其联合检测对原发性肝癌的早期诊断价值。方法:选择56例原发性肝癌患者、60名肝炎肝硬化患者和60名健康对照作为研究对象,分别应用比值法和化学发光法、生化法检测其血清AFP、AFU、β2-MG、CA199的含量。结果:原发性肝癌患者血清AFP、AFU、β2-MG、CA199含量均显着高于肝炎肝硬化组及健康对照组,差异均有统计学意义(P均<0.05);联合检测AFP、AFU、β2-MG、CA199四种肿瘤标志物,其阳性率达(85.7%)明显高于AFP(53.6%)、AFU(55.4%)、β2-MG(48.2%)和CA199(42.9%)单项检测组(P均<0.05);且AFP、AFU、β2-MG、CA199四种肿瘤标志物联合检测的敏感性均高于单一检测指标,差异有统计学意义(P<0.05),但其特异性显著低于AFU、β2-MG单项检测(P<0.05)。结论:联合检测血清AFP、AFU、β2-MG、CA199含量可以提高对原发性肝癌的阳性诊断率,对诊断及鉴别诊断原发性肝癌具有重要意义。
Objective：To investigate serum AFP,AFU,β2-MG,CA199 contents of primary hepatocellular carcinoma patients and the diagnostic value of combined detection on early primary hepatocellular carcinoma.Methods：Each application ratio method and chemiluminescence method,biochemical method in 56 cases of primary liver cancer patients with serum AFP,AFU,β2-MG,CA199 content detection,And in 60 patients with liver cirrhosis and 60 healthy controls were compared.Results：Primary carcinoma of the liver in patients with serum AFP,AFU,β2-MG,CA199 was significantly higher than that in liver cirrhosis patients and normal controls,The differences were statistically significant（P0.05）;The combined detection of AFP,AFU,β2-MG,CA199 four tumor markers,The positive rate（85.7%） was significantly higher than that of AFP（53.6%）,AFU（55.4%）,β2-MG（48.2%） and CA199（42.9%） individual testing group（P0.05）;And AFP,AFU,β2-MG,CA199 four tumor markers detection sensitivity is higher than that of single index,And AFP,AFU,β2-MG,CA199 four tumor markers detection sensitivity is higher than that of single index,But AFU,β2-MG individual specificity in detecting a joint detection group.Conclusion：Combined detection of serum AFP,AFU,β2-MG,CA199 content can improve the positive rate of diagnosis of primary carcinoma.
出处
《现代生物医学进展》
CAS
2012年第36期7124-7127,共4页
Progress in Modern Biomedicine
关键词
原发性肝癌
甲胎蛋白
а-L岩藻糖苷酶
Β2-微球蛋白
糖类抗原-199
Primary hepatocellular carcinoma（PHC）
Alpha-fetoprotein（AFP）
а-L fucosidase（AFU）
Beta 2 microglobulin（β2-M G）
Carbohydrate antigen-199（CA199）
