摘要
目的:探讨支气管哮喘患儿肺炎支原体、白介素-4(IL-4)及γ-干扰素(IFN-γ)检测的意义。方法:选择支气管哮喘患儿70例,其中合并肺炎支原体感染30例为观察组,未合并肺炎支原体感染40例为对照组,另选择35例健康儿童为健康组,检测并比较各组IL-4及IFN-γ水平。结果:(1)支气管哮喘患儿伴有肺炎支原体感染的比例为42.9%。与健康组相比,观察组及对照组患儿IL-4水平均显著升高,IFN-γ水平均显著降低,差异均有统计学意义(P<0.05)。与对照组相比,观察组患儿IL-4水平更高,IFN-γ水平更低,差异有统计学意义(P<0.05)。(2)经二分类Logistic回归分析,显示血清IL-4及IFN-γ水平为支气管哮喘患儿合并支原体感染重要危险因素(P<0.05)。结论:支气管哮喘合并肺炎支原体感染患儿IL-4水平显著升高,IFN-γ水平显著降低,两者均为其重要危险因素。
Objective. To investigate the value of Mycoplasma pneumoniae and serum IL-4, IFN-r detection in diagnosis of pediactric bronchial asthma. Methods. A total of 70 asthmatic children were cho- sen, 30 cases complicated with Mycoplasma pneumoniae infection as the observation group, 40 cases without Mycoplasma pneumoniae infection as the control group, while 35 healthy children were selected for the healthy group. The IL-4 and IFN-r/levels were detected and compared. Results. Incidence of bron- chial asthma with Mycoplasrna pneurnoniae infection in children was 42. 9M. Compared to the healthy group, IL-4 in the observation group and the control group children were significantly elevated, IFN-r was significantly reduced, and the differences were statistically significant （P〈0.05）. Compared with the con- trol group, IL-4 level of observation group was significantly higher, and the level of IFN-＇/was significant-ly lower, and the difference was statistically significant （P〈0. 05）. Binary logistic regression analysis showed that serum IL-4 and IFN-r levels were risk factors for children bronchial asthma with mycoplasma infection （P〈0.05）. Conclusion： Bronchial asthma with Mycoplasma pneumoniae infection in children has increased IL-4 levels, and significant decrease in the level of IFN-r, both of which are important risk factors.
出处
《海南医学院学报》
CAS
2013年第2期244-246,共3页
Journal of Hainan Medical University
基金
中国高校医学期刊临床专项资金项目(112210527)~~
