摘要
目的比较血清降钙素原(procalcitonin,PCT)和C-反应蛋白(C-reaction protein,CRP)在重症急性胰腺炎(severe acute pancreatitis,SAP)患者中的表达,评价其诊断疗效,探讨其临床适用性。方法选择从2010年5月至2012年5月于我院就诊的108例患者,实验组68名患者确诊为重症急性胰腺炎,其中合并感染者48人,未合并感染患者20人;其余对照组的40名为体检健康者。采用用化学免疫发光法和免疫比浊法,分别检测这些患者的血清PCT和CRP水平,并进行回顾性分析。结果 PCT、CRP在SAP合并感染组和未合并感染组中的表达均高于对照组,差异有统计学意义(P<0.05);SAP感染组CRP表达、PCT表达均比未感染组增高,两组数据差异有统计学意义(P<0.05)。SAP感染组、未感染组PCT表达与CRP表达无明显差异(P>0.05)。结论 PCT和CRP可以作为SAP患者的常规监测指标,尤其是可用来观察患者是否并发感染,同时为SAP患者的早期诊断分型、判断病情与预后以及疗效观察提供重要的参考。
Objective To compare the expression of serum procalcitonin （PCT） and C-reactive protein （CRP） in patients with severe acute pancreatitis （SAP）, evaluate the diagnostic efficacy, and explore its clinical applicability. Methods 68 patients diagnosed with severe acute pancreatitis in our hospital from May 2010 to May 2012 were selected as experimental group, including 48 cases of co-infection and 20 cases of non-infection. 40 cases of healthy subjects at the corresponding period in our hospital were selected as the control group. All cases were detected the serum PCT and CRP levels by chemical immunofluorescence technique and immune turbidimetry. Results The expressions of PCT and CRP in the experimental group were higher than those in the control group, and the difference was statistically significant （P〈0.05）. The patients with SAP co-infection had higher PCT and CRP expressions compared with patients without co-infection, and the difference was statistically significant （P 〈0.05）. PCT and CRP expressions between SAP infected group and un-infected group had no significant difference （P 〉0.05）. Conclusions PCT and CRP as routine monitoring indicators in patients with SAP, in particular, can be used to observe the concurrent infection, and provide an important reference for early diagnosis and typing of patients with SAP, determination of the disease condition, prognosis and observation of curative efficacy.
出处
《临床医学工程》
2013年第2期177-178,共2页
Clinical Medicine & Engineering
