摘要
依替米星 10 0、2 0 0和 40 0 mg/(kg· d) ,sc给于 SD雄、雌性大鼠分别连续 9周和 2周后合笼 ,雄鼠给药至 11周 ,雌鼠给药至妊娠第 15天。实验结果表明 ,40 0 mg/(kg·d)对雄鼠、雌鼠及胎仔均有毒性 ,表现为雄鼠从给药第 4周起体重增长受到抑制 (给药 4、5、周 P<0 .0 5 ,P<0 .0 1) ,雌鼠交配前和交配后体重增长也受到抑制 (交配前给药第 11、14天 ,P<0 .0 5 ,P<0 .0 1,交配后怀孕第 7、11～ 15天 ,P<0 .0 5 ) ,且孕鼠的黄体数减少 (P<0 .0 1) ,胎仔骨骼检查见胸骨节第一中心及耻骨未骨化 ,剑突和指 ,趾骨化点减少。 2 0 mg/(kg·d)对雄、雌大鼠的体重、交配率、妊娠率 ,孕鼠的黄体数 ,着床数 ,活胎、死胎数及胎仔体重、外形、内脏组织 ,骨骼均无影响。因此依替米星是不具有一般生殖毒性的药物。
Etimicin was studied in rats for general reproductive toxicity. Male and female SD rats were naturally bed and randomly assigned to four dosage groups with 20 rats per group respectively. Etimicin was a dministered subcutaneouly to male rats at dosage of 0, 100, 200 and 400mg/(kg·d) for 9 weeks before and during the mating period, and to female rats at the same dose levels from day 14 before mating through day 17 after gestation using a dosage volume of 2 ml/kg. Compared to the vehicle, the 400 mg/(kg·d) dosages of etimicin significantly decreased body weight of male rats (from week 4 of administered) and female rats (before mating and during the gestation) and decresed numbers of corpora lutea. The variation of fetal skeletal, such as not ossified of sternal centra (lst) and decreased ossification sites of xiphoid and digits, were detected in the animals with the same dosages. The 200mg/(kg·d) of dosages of etimicin, no dose related changs were observed in body weight, mating and fertility ratios of parent animals, numbers of corpora lutea and implantations; body weight of fetuses,fetal external,visceral and skeletal anomalies. Therefore, it can be concluded that etimicin is not a hazard to general reproductive toxicity.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2000年第B05期59-62,共4页
Chinese Journal of Antibiotics
