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肝动脉插管自体骨髓干细胞移植治疗失代偿期肝硬化150例临床观察

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摘要 目的:探讨肝动脉插管自体骨髓肝细胞移植对肝硬化患者的治疗作用。方法:收治失代偿期肝硬化患者150例,其中肝炎肝硬化130例、酒精性肝病20例,其中酒精致肝硬化肝性脊髓病1例。年龄25~68岁。从患者髂后上棘抽取骨髓,体外分离纯化骨髓源性干细胞,通过肝动脉置管移植入肝脏,在移植后10、20、30天复查肝脏功能,观察实验室指标改善、Child-Turcotte-Pugh分数变化及不良反应情况。结果:移植后第10天,患者血浆白蛋白由30.12±5.57g/L升至36.33±5.44g/L,丙氨酸转氨酶由术前85.71±82.86U/L。降至65.37±16.37U/L(P<0.01)。凝血酶原时间从移植前的15.55±3.71秒逐渐下降至移植后的14.41±2.93秒,纤维蛋白原从2.12±0.77g/L逐渐升高至2.94±0.77g/L。凝血酶原活动度100%患者不同程度升高,由治疗前平均25.18±14.8%上升至30天52.65±22.8%。干细胞移植术后患者临床症状明显改善,其中食欲改善、体力好转138例(92.0%),腹水减少或消失及下肢浮肿减轻134例(89.3%),腹胀减轻140例(93.3%)。近期未发生与干细胞移植相关的并发症。结论:骨髓干细胞移植是治疗失代偿期肝硬化患者安全、有效的方法。
出处 《中国社区医师(医学专业)》 2013年第4期33-34,共2页
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  • 1[1]Ganji A,Safavi M,Nouraie SM,Nasseri-Moghadam S,Merat Sh,Vahedi H,Malekzadeh R.Digestive and liver diseases statistics in several referral centers in Tehran,2000-2004.Govaresh 2006; 11:33-38
  • 2[2]Malek-Hosseini SA,Mehdizadeh AR,Salahi H,Saberi-Firouzi M,Bagheri-Lankarani K,Bahador A,Imanieh MH,Nik-Eghbalian S,Lahsaee M,Khosravi MB,Arasteh MM,Bagheri MH,Geramizadeh B,Razmkon A,Tabei SZ.Results of liver transplantation:analysis of 140 cases at a single center.Transplant Proc 2005; 37:3157-3158
  • 3[3]Sakaida I,Terai S,Nishina H,Okita K.Development of cell therapy using autologous bone marrow cells for liver cirrhosis.Med Mol Morphol 2005; 38:197-202
  • 4[4]Schachinger V,Erbs S,Elsasser A,Haberbosch W,Hambrecht R,Holschermann H,Yu J,Corti R,Mathey DG,Hamm CW,Suselbeck T,Assmus B,Tonn T,Dimmeler S,Zeiher AM.Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction.N Engl J Med 2006; 355:1210-1221
  • 5[5]Almeida-Porada G,Porada CD,Chamberlain J,Torabi A,Zanjani ED.Formation of human hepatocytes by human hematopoietic stem cells in sheep.Blood 2004; 104:2582-2590
  • 6[6]Sakaida I,Terai S,Yamamoto N,Aoyama K,Ishikawa T,Nishina H,Okita K.Transplantation of bone marrow cells reduces CCl4-induced liver fibrosis in mice.Hepatology 2004;40:1304-1311
  • 7[7]am Esch JS 2nd,Knoefel WT,Klein M,Ghodsizad A,Fuerst G,Poll LW,Piechaczek C,Burchardt ER,Feifel N,Stoldt V,Stockschlader M,Stoecklein N,Tustas RY,Eisenberger CF,Peiper M,Haussinger D,Hosch SB.Portal application of autologous CD133+ bone marrow cells to the liver:a novel concept to support hepatic regeneration.Stem Cells 2005; 23:463-470
  • 8[8]Montazeri A,Goshtasebi A,Vahdaninia M,Gandek B.The Short Form Health Survey (SF-36):translation and validation study of the Iranian version.Qual Life Res 2005; 14:875-882
  • 9[9]Mohyeddin Bonab M,Yazdanbakhsh S,Alimoghaddam K,Talebian F,Hooshmand F,Lotfi J,Ghavamzadeh A.Mesenchymal stem cell therapy for multiple sclerosis.Int J Hematol Oncol BMT 2005; 2:10-16
  • 10[10]Snyder EY,Daley GQ,Goodell M.Taking stock and planning for the next decade:realistic prospects for stem cell therapies for the nervous system.J Neurosci Res 2004; 76:157-168

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