摘要
目的通过比较辛夷不同组分抗过敏作用活性的强弱,确定辛夷抗过敏的有效组分,为指导临床用药及重大创新药物的研发提供参考及思路。方法分别给小鼠辛夷醇提组分、水提组分、挥发油组分,观察小鼠抗过敏性毛细血管通透性增强实验和皮肤被动过敏反应实验,比较辛夷不同组分抗过敏作用活性的大小。结果通过比较获知辛夷不同提取组分抗过敏作用强度为:醇提组分作用最强,水提组分和挥发油组分作用次之,两者差异不明显;醇提组分与水提组分或与挥发油组分比较,均呈现明显差异。结论辛夷不同组分抗过敏作用活性大小为:醇提组分>水提组分>挥发油组分,抗过敏活性导向下辛夷的有效组分为醇提取组分,但是鉴于中药多组分、多靶点、多途径的药效特点,以及辛夷多组分之间的相互作用及作用机制并不是十分明确,因此有必要进行多组分物质基础下的辛夷多组分之间药理作用及分子机制相关性研究,为更好的指导临床用药及创新药研发提供参考和思路。
Objective The effective ingredients of Magnolia for anti-anaphylaxis were preliminarily confirmed by compare with the different components＂ antiaUergic effects, in order to provide references and research ideas for innovative drugs. Methods The mice＇s anti-permeability strengthening of allergenic capillary vessels and passive anaphylaxis of the skin to select the effective ingredients of Magrlolia for anti-anaphylaxis were preliminarily observed after given alcohol extract,water extract and volatile oil components to compare with the different components＂ antiallergic effects. Results The antiallergenic effect of alcohol extract was the most effective, and the water extract and volatile oil components were inferior which had no obvious difference between the latter two groups, and there were obvious differences of the antiallergenic effect between the alcohol extract and water extract or volatile oil components by compareing the antiallergenic effect of different extract of F1os Magnolia. Conclusion The antiallergenic activity of the different ingredients from Flos Magnolia were alcohol extract 〉water extract〉 volatile oil components, and under the guidance of antiallergenic activity, the effective ingredients of F1os Magnolia was the alcohol extract. But as the complex of pharmacodynamics characteristics of TCM and the interaction between the components and molecular mechanisms of Flos Magnolia were not very clear, so it is necessary to take more research of the multi-components between the pharmacological and molecular mechanisms, in order to provide references and research ideas for inno- vative drugs.
出处
《中国药物警戒》
2013年第2期71-73,共3页
Chinese Journal of Pharmacovigilance
基金
国家重大新药创制重大专项课题
中药复方药理学研究与药效评价关键技术研究(2009ZX09502-015)
山东省科技攻关课题
辛夷抗过敏性鼻炎的实验与临床研究
(1997)年第971226313号
关键词
辛夷
不同组分
抗过敏作用
Flos Magnolia
different components
anti-anaphylaxis
