摘要
目的:观察人参养荣汤加减方联合化疗治疗中晚期气阴两虚型肺癌的临床疗效。方法:将60例中晚期气阴两虚型肺癌患者随机分为化疗组和人参养荣汤+化疗组各30例。化疗组仅采用西医方案化疗,人参养荣汤+化疗组在对照组的基础上同时给予中药人参养荣汤加减方配合治疗。连续治疗3个月后,观察化疗组和人参养荣汤+化疗组患者治疗前后近期疗效、生活质量改善、体质量变化、外周血象、免疫功能改善以及不良反应发生情况。结果:人参养荣汤+化疗组和化疗组总有效率分别为86.67%,63.33%,人参养荣汤+化疗组近期疗效明显优于化疗组,呈显著性差异(P<0.05);人参养荣汤+化疗组和化疗组患者生活质量提高率分别为60%,33.33%,人参养荣汤+化疗组明显优于化疗组,呈显著性差异(P<0.05);治疗前后人参养荣汤+化疗组和化疗组的体质量变化好转率分别为16.67%,13.33%,无统计学意义;人参养荣汤+化疗组出现外周血象异常情况明显低于化疗组,具有显著性差异(P<0.05);人参养荣汤+化疗组和化疗组治疗前后比较,CD4+,CD8+,CD4+/CD8+和自然杀伤(NK)细胞活性等免疫指标均呈现不同程度的显著性差异(P<0.05或P<0.01),人参养荣汤+化疗组免疫力明显得到提高;与化疗组比较,人参养荣汤+化疗组不良反应发生率明显低于对照组,呈现显著性差异(P<0.05)。结论:人参养荣汤加减方联合化疗药物治疗气阴两虚型中晚期肺癌能有效缓解患者临床症状,提高机体免疫力,减少毒副反应,提高生活质量,两者起到协同增效减毒效果,值得临床推广和应用。
Objective： To investigate the clinical efficacy of treatment on the Qiyinliangxu type lung cancer of Renshen Yangrong soup plus and minus combined with chemotherapy. Method ： Sixty cases of Qiyinliangxu type lung cancer in middle and late period were randomly grouped to chemotherapy group and Renshen Yangrong soup combined with chemotherapy group, each group for 30 cases. The chemotherapy groups were only used western medicine chemotherapy scheme, and the Renshen Yangrong soup combined with chemotherapy groups were cured together with Renshen Yangrong soup based on the treatment of control group. After 3 months＇ treatment continuously, the short term curative effect, the improvement of life quality, the changes of body weight, the improvement of peripheral blood and immune function, and the occurrence of adverse reaction were observed. Result ： The total effectiveness of chemotherapy group and Renshen Yangrong soup combined with chemotherapy group were respectively 86.67% and 63.33%, the short term curative effect of Renshen Yangrong soup combined with chemotherapy group was better than the chemotherapy group, and there was significant difference（P＜0.05）; the improvement rate of life quality was respectively 60.0% and 33.3%, the Renshen Yangrong soup combined with chemotherapy group was better than the chemotherapy group, and there was significant difference （P＜0.05）; the improvement rate of body weight was respectively 16.67% and 13.33%, and there was no significant difference （P＞0.05）; the peripheral blood abnormality rates of Renshen Yangrong soup combined with chemotherapy group were obviously lower than the chemotherapy group, and there was significant difference （P＜0.05）; the Renshen Yangrong soup combined with chemotherapy and chemotherapy group were compared before and after treatment, the immune indexes （CD4＋, CD8＋, CD4＋/CD8＋ and the activity of NK cell） all presented significant difference of different degree （P＜0.05 and P＜0.01）, and the immunity of Renshen Yangrong soup combined with chemotherapy group was obviously improved; compared with chemotherapy group, the occurrence rate of adverse reaction of Renshen Yangrong soup combined with chemotherapy group was obviously lower than chemotherapy group, and there was significant difference （P＜0.05）. Conclusion ： The Qiyinliangxu type lung cancer was cured with Renshen Yangrong soup plus and minus combined with chemotherapy, and it could effectively relieve the clinical symptoms, improve the immunity, reduce the occurrence of adverse reaction, and improve the life quality, and the TCM combined with chemotherapy had the efficacy improved and toxicity lowered, and it was worthy popularized and applied in clinic.
出处
《中国实验方剂学杂志》
CAS
北大核心
2013年第5期312-316,共5页
Chinese Journal of Experimental Traditional Medical Formulae
关键词
人参养荣汤加减
化疗
气阴两虚
肺癌
临床疗效
Renshen Yangrong soup
chemotherapy
Qiyinliangxu type
lung cancer
clinical efficacy
