期刊文献+

新型负载5-氨基水杨酸微胶囊的制备及其载药效果 被引量:4

Preparation of Novel Microcapsules Loading 5-Aminosalicylic Acid and Their Loading and Encapsulation Efficiency
原文传递
导出
摘要 采用锐孔/聚合法制备了平均粒径为1.89mm、负载5-氨基水杨酸(5-ASA)的纤维素硫酸钠(NaCS)-壳聚糖微胶囊,采用Box-Behnken响应面法进行实验设计和分析,考察了内、外水相pH值和NaCS浓度、多聚磷酸钠(PPS)浓度对微胶囊载药量和包封率的影响.结果表明,内水相pH值对负载5-ASA微胶囊的载药量和包封率起关键作用.最佳制备条件为内水相pH4.25,外水相pH6.0,NaCS浓度14g/L,PPS浓度5g/L,该条件下所制微胶囊最大载药量为59.02%,最大包封率为89.96%.. The microcapsules loading 5-aminosalicylic acid (5-ASA) were prepared with sodium cellulose sulfate (NaCS) and chitosan via orifice-polymerization method, and their average diameter was 1.89 mm. The effects of pH values of inner water and outer water phases, concentrations of NaCS and sodium polyphosphate (PPS) on the drug loading rate and encapsulation rate ofmicrocapsules were mainly investigated. Box-Behnken method was used to design the experiments. The results showed that the pH value of inner water phase played a key role to the drug loading and encapsulation rates of microcapsules. The optimal conditions were pH values of inner and outer phases 4.25 and 6.0, concentrations of NaCS and PPS 14 and 5 g/L, the drug loading and encapsulation rates of microcapsules were 59.02% and 89.96%, respectively.
出处 《过程工程学报》 CAS CSCD 北大核心 2013年第1期117-123,共7页 The Chinese Journal of Process Engineering
基金 国家自然科学基金重点资助项目(编号:21036005) 高等学校博士学科点专项基金重点资助项目(编号:20110101130007)
关键词 5-氨基水杨酸 锐孔 聚合法 微胶囊 载药量 包封率 5-aminosalicylic acid orifice-polymerization method microcapsule drug loading rate encapsulation rate
  • 相关文献

参考文献17

  • 1Parakkal D, Thorpe M, Paver S, et al. A Comparison of Dynamic Systems Models of Gastrointestinal Kinetics of Controlled Release Multimatrix System 5-Aminosalicylic Acid (5-ASA), Lialda (tm) with pH-dependent, Delayed Release 5-ASA [Asacol (tm)] [J]. Am. J. Gastroenterol., 2010, 105: S475.
  • 2Mahajan N, Sakarkar D, Manmode A, et al. Biodegradable Nanoparticles for Targeted Delivery in Treatment of Ulcerative Colitis [J]. Adv. Sci. Lett., 2011, 4(2): 349-356.
  • 3Di Pretoro G, Zema L, Palugan L, et al. Optimisation and Scale-up of a Highly-loaded 5-ASA Multi-particulate Dosage Form Using a Factorial Approach [J]. Eur. J. Pharm. Sci., 2012, 45(1/2): 158-168.
  • 4Mura C, Naeher A, Merino V, et al. Design, Characterization and in vitro Evaluation of 5-Aminosalicylic Acid Loaded n-Succinyl- Chitosan Microparticles for Colon Specific Delivery [J]. Colloids Surf. B: Biointerf., 2012, 94: 199-205.
  • 5Xie Y L, Wang M J, Yao S J. Preparation and Characterization of Biocompatible Microcapsules of Sodium Cellulose Sulfate/Chitosan by Means of Layer-by-layer Self-assembly [J]. Langmuir, 2009, 25(16): 8999-9005.
  • 6谢瑜亮,王明君,姚善泾.层层自组装纤维素硫酸钠-壳聚糖复合膜[J].化工学报,2008,59(11):2910-2915. 被引量:9
  • 7刘川,朱丽英,林东强,姚善泾.微流芯片制备粒径均一的壳聚糖-NaCS/TPP微胶囊[J].化工学报,2012,63(1):216-222. 被引量:3
  • 8Yao S J. Verfahrenstechniche Auslegtmg einer Anlage fuer NaCS Herstellung zur Immobiliserung von Biokatalysatoren [D]. Berlin: Technische Universitaet Berlin, 1996. 57-90.
  • 9Wang M J, Xie Y L, Zheng Q D, et al. A Novel, Potential Microflora-activated Carrier for a Colon-specific Drug Delivery System and Its Characteristics [J]. Ind. Eng. Chem. Res., 2009, 48(11): 5276-5284.
  • 10Yao S J. An Improved Process for the Preparation of Sodium Cellulose Sulphate [J]. Chem. Eng. J., 2000, 78(2/3): 199-204.

二级参考文献35

  • 1刘亚军,朱以华,张素秋,杨晓玲.以三聚氰胺甲醛微球为模板的空腔胶囊的制备与应用[J].过程工程学报,2004,4(6):513-518. 被引量:6
  • 2Claire S P,Lars D.Tailor-made Polyelectrolyte Microcapsules:From Multilayers to Smart Containers[J].Angew.Chem.Int.Ed.,2004,43:3762-3783.
  • 3Feng Z Q,Wang Z P,Gao C Y,et al.Hollow Microcapsules with a Complex Polyelectrolyte Shell Structure Fabricated by Polymerization of 4-Vinylpyridine in the Presence of Poly(sodium 4-styrenesulfonate) and Silica Particles[J].Mater.Lett.,2007,61:2560-2564.
  • 4Sukhorukov G,Fery A,M6hwald H.Intelligent Micro-and Nanocapsules[J].Prog.Polym.Sci.,2005,30:885-897.
  • 5Caruso F,Caruso R A,Mohwald H.Nanoongine,ering of Inorganic and Hybrid Hollow Spheres by Colloidal Templating[J].Science,1998,282:1111-1113.
  • 6Decher G Fuzzy Nano Assemblies:Toward Layered Polymeric Multicomposites[J].Science,1997,277:1232-1237.
  • 7Yang X L,Han X,Zhu Y H.(PAH/PSS)5 Microeapsules Templated on Silica Core:Encapsulation of Antieancer Drug DOX and Controlled Release Study[J].Colloids Surf.A:Physicochem.Eng.Aspects,2005,264:49-54.
  • 8Alexandr S A,Betmo R,Frank C.Light-responsive Polyelectrolyte/Gold Nanoparticle Microcapsules[J].J.Phys.Chem.B,2005,109:3071-3076.
  • 9Frank C,Yang W J,Dieter T,et al.Microencapsulation of Uncharged Low Molecular Weight Organic Materials by Polyelectrolyte Multilayer Self-assembly[J].Langmuir,2000,16:8932-8936.
  • 10Tong W J,Gao C Y.Stable Microcapsules Assembled Stepwise from Weak Polyelelctrolytes Followed by Thermal Crosslinking[J].Polym.Adv.Technol.,2005,16:827-833.

共引文献17

同被引文献44

  • 1苗宗成,王蕾,王登武,杨建洲.可生物降解的基于孪联十八烷基二甲基叔胺阳离子表面活性剂的制备[J].湖北农业科学,2013,52(17):4179-4181. 被引量:4
  • 2张永,王学谦,宁平,户朝帅.碳酸钠溶液吸收处理硫化氢试验研究[J].云南化工,2006,33(2):32-34. 被引量:20
  • 3陈烨璞,史春薇,陈欣.壬二酸研究的进展[J].临床和实验医学杂志,2006,5(1):48-49. 被引量:5
  • 4张宜,刘珍勇.壬二酸临床前药学研究进展[J].中国药业,2007,16(18):57-58. 被引量:9
  • 5李阳初,刘雪暖.石油化学工程原理[M].北京:中国石化出版社,2008.
  • 6GBZ2.1-2007.工作场所有害因素职业接触限值-第1部分:化学有害因素[S].
  • 7Garner F H, Long R, Pennell A. The Selective Absorption of Hydrogen Sulphide in Carbonate Solutions [J]. J. Appl. Chem., 1958, 8(5): 325-336.
  • 8Dubois L, Thomas D. Comparison of Various Alkaline Solutions for H2S/CO2-selective Absorption Applied to Biogas Purification [J]. Chem. Eng. Technol., 2010, 33(10): 1601-1609.
  • 9Bontozoglou V, Karabelas A J. Numerical Calculation of Simultaneous Absorption of H2S and CO2 in Aqueous Hydroxide Solutions [J]. Ind. Eng. Chem. Res., 1991, 30(12): 2598-2603.
  • 10Hinz A, Wallin M. Individual and Simultaneous Desorption of H2S and CO2 from Synthetic Green Liquor [J]. Chem. Eng. J., 1999, 72(1) 63-77.

引证文献4

二级引证文献5

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部