摘要
目的:探讨EphA2和E-cad在NSCLC(non-small cell lung cancer,非小细胞肺癌)中的表达情况及与临床病理特征的关系,并研究EphA2过表达与E-cad表达的相关性,探讨EphA2过表达可能的机制,筛选出能反映肿瘤预后的相关指标。方法:运用免疫组织化学Envision法检测62例NSCLC中EphA2和E-cad的表达情况。结果:1.EphA2在62例NSCLC的阳性表达率为50%(31/62),EphA2的阳性表达率与有淋巴结转移、临床分期晚、5a生存率有关(P<0.05),而与患者吸烟与否、肿瘤的组织学类型和分化程度无关(P>0.05)。EphA2阴性组的生存时间长于阳性组,有统计学意义(P<0.01)。2.E-cad在62例NSCLC的异常表达率为53.2%,E-cad的异常表达率与有淋巴结转移、临床分期晚和5a生存率有关(P<0.01)。与患者吸烟与否、肿瘤的组织学类型和分化程度无关(P>0.05),E-cad正常表达组的生存时间长于异常表达组,有统计学意义(P<0.01)。3.EphA2与E-cad的表达呈负相关性(P<0.01)。结论:在NSCLC中EphA2的过表达及E-cad的低表达与肿瘤的淋巴结转移、临床分期及术后生存时间有关,因此可作为判断NSCLC预后的指标。
Objective：To investigate the expression level of EphA2 and E - cad in non - small cell lung cancer （NSCLC） and their relationship with the clinicopathological features. To study the correlation among the expression of EphA2 and E - cad. To screen the possible index to predict the prognosis of NSCLC patients. Methods：To investigate the expression level of EphA2 and E - cad in 62 ca- ses of NSCLC by Envision immunohistochemical method. Results：l. Overexpression of EphA2 in 62 NSCLC specimens was 50%. E- phA2 levels did not appear to relate to smoke, histological type or differentiation, but did relate to lymph node metastasis, clinical stage （P 〈 0.01 ） and 5 year survival rate（ P 〈 0.05 ）. There was longer survival time in EphA2 negative cases than in positive cases （P 〈 O. 01 ）. 2. Abnormal expression rate of E - cad in 62 NSCLC specimens was 53.2%. The abnormal expression rate of E - cad did not ap- pear to relate to smoke, histological type or differentiation, but did relate to lymph node metastasis, clinical stage and 5 year survival rate（ P 〈0.01 ）. There was longer survival time in E -cad normal expression cases than in abnormal expression cases and their differ- ence was significant（ P 〈 0.01 ） 3. Expression of EphA2 correlate to E- cad abnormal expression（ P 〈 0.01 ）. Conclusion：The overex- pression of EphA2 and low expression of E - cad are observed in NSCLC, which might be related to lymph node metastasis,clinical stage and survival time. Hence they might Be contribute to prognostic judgment.
出处
《牡丹江医学院学报》
2013年第1期5-9,共5页
Journal of Mudanjiang Medical University
