摘要
阿尔茨海默病是一种常见的神经退行性疾病。果蝇以其独特的分子遗传学优势成为研究阿尔茨海默病的理想模型。通过果蝇模型的研究不仅可以揭示阿尔茨海默病的发病机制,还可以提供相关药物筛选模型。本文对近年来利用转基因果蝇模型进行阿尔茨海默病研究的进展情况作一综述。
Alzheimer disease （AD） is a common neurodegenerative disease. Drosophila has been regard as one of the ideal models for Alzheimer because of its unique advantage on genetic manipulation. AD transgenicdrosophila models not only help to elucidate the pathogenesis of Alzheimer disease, but also provide potential screening models for drugs to treat the disease. In this review, we summarize the recent research progress using AD transgenic drosophila.
出处
《药学学报》
CAS
CSCD
北大核心
2013年第3期333-336,共4页
Acta Pharmaceutica Sinica
关键词
转基因
果蝇
阿尔茨海默病
transgenic
drosophila
Alzheimer disease
