摘要
目的:观察直接灸四花穴对非小细胞肺癌化疗患者免疫功能的作用及生存质量的影响。方法:将80例非小细胞肺癌患者随机分为化疗加艾灸组(40例)和单纯化疗组(40例)。两组均采用诺维本+顺铂(NP)化疗方案,化疗加艾灸组化疗同时采用直接灸四花穴(膈俞穴、胆俞穴)治疗,每穴施灸3壮,每天1次,10天为一疗程,共观察1个疗程。比较两组患者治疗前后集落刺激因子(CSF)、肿瘤坏死因子(TNF)、白细胞介素-2(IL-2)及卡劳夫斯基(Karnofsky)体力评分的变化。结果:治疗后化疗加艾灸组患者血清CSF、IL-2水平较单纯化疗组升高(均P<0.01),TNF水平较单纯化疗组降低(P<0.01);治疗后两组Karnofsky体力评分均较治疗前下降(均P<0.01),但化疗加艾灸组Karnofsky体力评分较单纯化疗组高(P<0.01)。结论:直接灸四花穴能提高肺癌化疗患者血清CSF、IL-2水平,降低TNF水平,从而提高患者免疫功能及临床疗效,改善其生存质量。
Objective To observe the effect of direct moxibustion at Sihua points on immune function and life quality of chemotherapy patients with non-small cell lung cancer. Methods Eighty cases were randomly divided in- to a chemotherapy and moxibustion group （group A） and a chemotherapy group （group B）, 40 cases in each one. Navelbine and cisplatin were applied in both groups. In addition, direct moxibustion at Sihua points which inclu- ded Geshu （BL 17） and Danshu （BL 19） was used in the group A. Three moxa-cones were given on each acupoint, once a day, ten days treatment made one session and totally one session was required. The change of colony stimu- lating factor （CSF）, tumor necrosis factor （TNF）, interleukin-2 （IL-2） and Karnofsky scale was compared between the two groups before and after treatment. Results After the treatment, the levels of serum CSF, IL-2 in the group A were higher than those in the group B （both P〈0.01）, while the level of TNF in the group A was lower than that in the group ]3 （P〈C0.01）. Although Karnofsky score was decreased in the two groups （both P~ 0.01）, the score in the group A was higher than that in the group ]3 （P^0.01）. Conclusion Direct moxibustion at Sihua points could increase the levels of CSF and IL-2 and reduce TNF in the chemotherapy patients with lung cancer, which could improve immune function, clinical efficacy and life quality.
出处
《中国针灸》
CAS
CSCD
北大核心
2013年第3期207-210,共4页
Chinese Acupuncture & Moxibustion
基金
广东省中医药局建设中医药强省科研课题项目:1060059
关键词
肺癌
化疗反应
灸法
穴
四花
穴
膈俞
穴
胆俞
细胞因子
lung cancer chemotherapy response
moxibustion therapy
Sihua Point, Point BL 17 （Geshu）lPoint BL 19（Danshu）
cytokine
