摘要
目的探讨糖皮质激素降阶梯疗法联合夫西地酸治疗婴儿湿疹的疗效及安全性。方法采用随机对照开放试验,将入选的160例患者随机分成4组,每组40例,治疗组采用降阶梯疗法,初诊时将糠酸莫米松乳膏和夫西地酸乳膏分别涂于患处,1次/d,待皮疹改善后单用丁酸氢化可的松乳膏外搽,2次/周;对照组分为A,B和C组,分别单用糠酸莫米松乳膏、丁酸氢化可的松乳膏和夫西地酸乳膏外搽患处,均1次/d,连用2周。于治疗第1和2周末及痊愈后1周和2周时随访,记录皮疹变化,评价红斑、丘疹、鳞屑、瘙痒及皮损面积总积分。结果治疗1周时,治疗组有效率(95.00%)高于其他3组(A组为87.50%,B组为75.00%,C组为22.50%);治疗2周时治疗组有效率(97.50%)高于A组(95.00%)和B组(92.50%),但差异均无统计学意义(P均>0.05)。痊愈1周后随访,治疗组复发率(5.26%)与A组(29.63%)、B组(30.00%)比较,差异有统计学意义(P均<0.05)。痊愈2周后随访,治疗组复发率(10.53%)与A组(34.29%)、B组(36.67%)比较,差异有统计学意义(P均<0.05)。结论应用糖皮质激素降阶梯疗法联合夫西地酸治疗婴儿湿疹疗效好,复发率低,且不良反应少。
Objective To explore the efficacy and safety of glucocorticoid de-escalation therapy combined with fusidic acid cream in the treatment of infantile eczema. Methods A randomized controlled open trial was performed. One hundred and sixty patients met the inclusion criteria were randomly divided into treatment group and control group A, B, C, each of 40 cases. De-escalation therapy was applied to the treatment group, mometasone furoate cream and fusidic acid cream were respectively applied to the lesion, once per day alternatively, and the later was maintained by butyrate hydrocortisone cream after the rash cured. Control group A, B, C were given mometasone furoate cream, hydrocortisone butyrate cream and fusidic acid cream therapy respectively for 2 weeks. The variations of the rash were recorded and the total scores of erythema, papule, scale, pruritus and area were evaluated in the return visit of 1,2 weeks after medication. Results The effective rate 97.50% of treatment group was higher than that in control group A （ 95. 00% ） and group B （92. 50% ） after 2 weeks of therapy, but there were no statistical difference between them. Recovered follow-up after one week, the recurrence rate of treatment group with 5.26% were significantly lower than those in group A（29.63% ） and group B（30.00% ）. After two weeks, the recurrence rate of treatment group with 10.53% were significantly lower than those in group A（34.29% ） and group B（36.67% ）. Conclusion Glucocorticoid de-escalation therapy combined with fusidic acid cream is an effective way with less adverse reaction and low recurrence rate in the treatment of infantile eczema.
出处
《中国皮肤性病学杂志》
CAS
北大核心
2013年第3期268-270,共3页
The Chinese Journal of Dermatovenereology
