摘要
研究糖尿病 (DM)人肝脏的超微结构变化。对 2 0例DM患者行肝穿活检 ,所取标本行光、电镜观察。光镜下见核内糖原空洞、脂肪变性及间质纤维化。电镜下见 :核内糖原颗粒 ;胞浆糖原颗粒增多 ;粗面内质网 (RER)脱粒 ;滑面内质网 (SER)扩张 ;线粒体 (Mi)肿胀 ,嵴紊乱 ,结构消失或电子密度增高 ,结构不清 ;脂肪变性 ;间质纤维化。DM肝超微结构改变中最具特征性的是核内糖原颗粒。
Objective:To study the changes of hepatic ultrastructure in patients with diabetes mellitus.Methods:Liver biopsy and pathological examination were carried out in 20 diabetes mellitus patients.Result Under light microscope,It showed that nuclear glycogen cavity,fatty degeneration and interstitial fibrosis.Whereas electron microscope:nuclear glycogen granules;glycogen granules in cytoplasm increase;rough endoplasmic reticulum degranulation;smooth endoplasmic reticulum expansion;mitochondrial swelling,crista disorder or electron density increase;fatty degeneration;interstitial fibrosis.Conclusion:The most characteristic change of hepatic ultrastructure is nuclear glycogen granules in diabetes mellitus.
出处
《临床肝胆病杂志》
CAS
北大核心
2000年第4期241-243,共3页
Journal of Clinical Hepatology
