摘要
循环肿瘤细胞(CTCs)作为研究肺癌转移过程的一个切入点正越来越引起人们的兴趣。十九世纪末关于肿瘤转移提出的"种子-土壤"学说已经预测了CTCs的存在。但是,近年来才建立了可靠的、重复性好的检测和分析CTCs的实验方法。目前,CellSearch检测法已被广泛应用于临床,并获得了美国FDA的认证。CTCs计数可以用于指导对转移性肿瘤患者的预后评估,并且能够反映抗肿瘤药物的疗效,还可以监测肿瘤的复发。对CTCs的分子及遗传学特征的分析使其有可能被视为是一种非侵入性的"液基活检",它能反映原发肿瘤组织的分子生物学及遗传学特征。本文就CTCs的生物学特征、在肿瘤转移过程中的作用、目前最常用的检测方法以及该方法在肺癌临床中的应用价值展开综述。
Circulating tumor cells（CTCs） are increasingly attracted the interest of the people as an entry point to study the process of lung cancer metastasis. The ＂seed-soil＂ hypothesis of the nineteenth century on tumor metastasis has predicted the existence of CTCs. But it was only in recent years, a reliable, reproducible experimental methods for the detection and analysis of CTCs has been established. Currently, CellSearch assay has been widely used in clinical and has been certified by the FDA. CTCs counts can be used to guide the prognosis of patients with metastatic tumors, reflect the efficacy of anticancer drugs, and can monitor tumor recurrence. A- nalysis of CTCs molecular and genetic characteristics may be regarded as a non-invasive ＂liquid-based biopsy＂ , and it can reflect the molecular biology and genetics characteristics of the primary tumor tissue. In this review, we will discuss the biological characteristics of CTCs, its role in the process of tumor metastasis, currently the most commonly used detection method and the clinical value in lung
出处
《临床肿瘤学杂志》
CAS
2013年第2期179-182,共4页
Chinese Clinical Oncology
关键词
循环肿瘤细胞
肺癌
免疫磁性检测法
预后
液基活检
Circulating tumor cells（CTCs）
Lung cancer
Immunomagnetic beed-based method
Prognosis
Liquid- based biopsy
