摘要
目的探讨可舒胶囊对酒精所致大鼠急性肝损伤的保护作用及机制。方法采用酒精灌胃辅以高脂饲料法复制急性酒精性肝损伤大鼠模型。50只雄性Wistar大鼠随机分为5组:正常对照组、急性酒精肝损伤模型组、可舒胶囊低、中及高剂量(3.06、6.12、12.24 g/kg)组,每组10只。测定并比较各组大鼠血清中核转录因子-κB(NF-κB)及肿瘤坏死因子-α(TNF-α)的含量。结果治疗后,与模型组比较,可舒胶囊各剂量组急性酒精性肝损伤大鼠血清NF-κB和血清TNF-α的含量降低(P<0.01)。结论舒胶囊通过抑制NF-κB和TNF-α,降低炎性因子水平,对酒精性肝损伤的肝功能具有保护作用。
Objective To investigate the protective effect of Keshu capsule on acute alcoholic liver injury in rats and its possi- ble mechanism. Methods The liver injury models were induced by infusing alcohol into stomach of rats, and feeding with fat-rich diet at the same time. Fifty male Wistar rats were randomly divided into 5 groups： control group, acute liver injury model group, and low, middle, high doses of Keshu capsule （ 3.06,6.12,12.24 g/kg） groups. The nuclear factor-kappa B （ NF-κB ） and tumor necrosis factor- α （TNF-α） content were assayed and compared between groups. Results Comparedl with model group, the serum concentrations of NF- KB and serum TNF-α content significantly decreased in Keshu capsule groups （P 〈 0. 01 ）. Conclusion Keshu capsule protected liver from alcoholic impairment through decreasing cytokine release followed suppressing NF-κB and TNF-α.
出处
《东南国防医药》
2013年第1期21-23,共3页
Military Medical Journal of Southeast China
