摘要
目的通过观察银杏叶提取物预处理前后S-100β、SjvO2、乳酸、PF、PLT等指标的变化,探讨银杏叶提取物在颅内血管手术围术期脑保护的作用。方法择期行颅内血管手术成年患者40例,随机分为银杏叶治疗组(Y组)和对照组(D组),每组20例。麻醉诱导后,银杏叶治疗组经静脉滴注银杏叶提取物注射液1 mg/kg(用生理盐水250 ml稀释),30 min滴完;对照组同速度输入等量生理盐水。分别于手术前(T0)、手术1 h(T1)、手术2 h(T2)、手术6 h(T3)、手术后12 h(T4)抽取颈静脉球部血测S-100β、SjvO2、乳酸、PF、PLT。结果两组T2、T3、T4的S-100β较T0升高,差异有统计学意义(p<0.05)。组间比较Y组T2、T3、T4的S-100β较D组明显降低(p<0.05)。两组T3、T4的SjvO2、乳酸比较有明显差异(p<0.05)。两组PF、PLT比较无明显差异(p>0.05)。结论在颅内血管疾病手术中给予银杏叶提取物预处理具有脑保护的作用,且对血小板功能无影响。
Objective In this observation, we try to discuss the perioperative cerebral protective effects of Ginkgo biloba extract in intracranial vascular operation through the S - 10013.SjvO2 ,LA,PF,PLT changes. Methods Forty patients, scheduled for elective intracranial vascular operation were enrolled in the study. And the patients were randomly allocated into two groups （20 in each group）, group Y and group D. After the induction of anesthesia, the patients of group Y were treated by intravenous injection of Ginkgo biloba extract on 1 mg/kg （0. 9% 250 ml of normal saline）, 30 min iv drip; group D by normal saline. We tested S - 100[3,SjvO2 ,LA,PF from jugular bulb blood before operation （ To ）, 1 hour after operation （ T1 ）, 2 hours after operation （ T2 ）, 6 hours after operation （Ts ）, 12 hours after operation （ T4 ）. Results S - 100β of two groups increased significantly at T2, T3, T4 （p 〈 0.05）. There was significant deviation for S - 100β of two groups at T2, T3, T4 （p 〈 0. 05 ）. There was significant difference in two groups of SjvO2 ,LA at T3 ,T4 （p 〈0.05 ）. PF and PLT of these two groups had no significant differ- ence （p 〉0. 05）. Conclusion There is cerebral protective effects of Ginkgo biloba extract in intracranial vascular disease operation and no effect on platelet function.
出处
《现代医院》
2013年第2期7-9,共3页
Modern Hospitals
基金
广州市中医药科技项目(编号:20112233010003)
