摘要
目的探讨慢性肾脏病(CKD)冠状动脉钙化发生率及其在预后评估中的应用。方法测定136例CKD患者及50例同期健康体检者血钙(Ca)、血磷(P)水平,并采用多层螺旋CT(MSCT)检测所有观察对象冠状动脉钙化积分情况。比较不同组间患者的冠状动脉钙化及主要心脏不良事件(MACE)发生情况。结果与对照组比较,三组不同CKD分期患者的冠状动脉钙化率、重度钙化率、血磷及钙磷乘积均明显升高(P〈0.05);且随着CKD病情程度的增加,患者冠状动脉钙化率、重度钙化率、钙磷乘积均依次增加(P〈0.05);随着透析治疗时间的延长,冠状动脉钙化率、重度钙化率均呈上升趋势(P〈0.05);随访1年,钙化组MACE发生率为16.9%,显著高于非钙化组为5.6%(P〈0.05)。结论CKD患者冠状动脉钙化发生率较高,尤其是长期维持性透析患者,且冠状动脉钙化程度与CKD患者的预后有关。
Objective To explore the incidence of coronary calcification in patients with chronic kidney disease ( CKD ) , and its prognosis evaluation value at a single center. Methods The blood calcium ( Ca ) and phosphate ( P ) in 136 CKD patients and 50 healthy persons were detected, and the coronary calcification score were measured by multi-slice spiral computed tomography ( MSCT ) . Result Compared with health controls, incidence of coronary calcification and severer coronary calcification, level of P and Ca-P product were significantly higher in CKD patients of different stages, and with the severity aggravating of CKD, incidence of coronary calcification and severer coronary calcification, level of Ca-P product were increased ( P〈0.05 ) . The incidence of coronary calcification and severer coronary calcification increased with the dialysis duration ( P〈0.05 ) . During 1 year follow-up, the incidence of MACE in calcification group was 16.9%, significantly higher than that of non- calcification group 5.6% ( P〈0.05 ) . Conclusions From our single center' s experience,patients with CKD has higher incidence of coronary calcification, especially for calcification is correlated with the prognosis of CKD. the long-term support dialysis patients, and the degree of coronary
出处
《浙江临床医学》
2013年第3期333-335,共3页
Zhejiang Clinical Medical Journal
关键词
慢性肾脏病
冠状动脉钙化
预后
Chronic kidney disease
Coronary calcification
Prognosis