摘要
目的转基因小鼠是进行肿瘤研究的良好材料，采用化学诱导剂在绿色荧光蛋白转基因C57BL／6小鼠（GFP—C57BL/6）上建立肿瘤模型。方法本研究采用苯并（α）芘对GFP—C57BL／6进行前胃癌的诱导实验。结果苯并（α）芘处理后30周，小鼠前胃肿瘤发生率达到100％，且不会照成对照小鼠胃部损伤。结论采用苯并（α）芘可以在GFP—C57BIM6小鼠成功建立肿瘤动物模型。
Chemically induced tumor model is one of common techniques for cancer research. The mouse of transgenic green fluorescent protein gene is also a good material. In the research, B （a）P was used to induce forestomach neoplasia in green fluorescent protein transfected C57BL/6 （ GFP - C57BL/6 ） mouse. The results show that the B（a） P can be induce forestomach neoplasia successfully. The tumor incidence reached 100% when the GFP -C57BL/6 was treated with B（a） P. It could be used for a inducer in GFP- C57BL/6 forestomach neo- plasia model
出处
《实用肿瘤学杂志》
CAS
2013年第1期51-53,共3页
Practical Oncology Journal
基金
黑龙江省科技技术项目（PC09S04）
黑龙江省普通高校病因流行病学开放课题（2012-8）
