摘要
目的:评价肝动脉介入联合靶向治疗结肠癌肝转移的疗效及药物不良反应。方法:78例结肠癌肝转移患者随机分为干预组和对照组,干预组(42例)应用肝动脉介入((TACE))联合靶向治疗方案治疗,对照组(36例)单纯采用肝动脉介入治疗(TACE)方案治疗。结果:干预组和对照组的近期有效率分别为80.9%和55.6%,差异有显著性意义(P﹤0.05)。治疗后0.5、1、2、3、5年生存率,干预组为94.3%,68.8%,33.7%,18.4%,10.3%,对照组为84.2%,54.6%,19.6%,8.1%,2.5%,两组之间差异有显著性意义(P﹤0.05)。在药物不良反应及并发症方面两组之间无显著性差异。结论:应用肝动脉介入联合靶向治疗结肠癌肝转移,优于单纯肝动脉介入治疗的效果。
Objective: To evaluate the hepatic artery interventional therapy combined with targeted therapy efficacy and adverse drug reactions in the treatment of colon cancer liver metastasis. Method: 78 cases of colon cancer patients with liver metastases were randomly divided into intervention group and control group, intervention group application hepatic artery intervention (TACE ) combined targeting treatment. Control group were treated with artery interventional therapy ( TACE ). Results: The intervention group and control group response rate was 80.9% and 55.6% respectively, the difference was significant (P 〈0.05 ). The survival rate after treatment 0.5,1,2,3,5 years, the intervention group was 94.3%, 68.8%, 33.7%, 18.4%, 10.3%, the control group was 84.2%, 54.6%, 19.6%, 8.1%, 2.5%. There was significance different between the two groups ( P 〈0.05 ). No significant differences in adverse drug reactions and complications between the two groups. Conclusion: The effect of hepatic artery interventional therapy combined with targeted therapy of colon cancer patients with liver metastases, is superior to simple hepatic artery interventional therapy.
出处
《河北医学》
CAS
2013年第4期546-549,共4页
Hebei Medicine
关键词
结肠癌肝转移
肝动脉介入治疗
靶向治疗
Colon cancer liver metastases
Hepatic artery interventional treatment
Targeted therapy